PARANEOPLASTIC SYNDROME IN PRIMARY HEAD AND NECK CANCER: A CASE REPORT
Abstract Introduction:We report the case of a patient who had a paraneoplastic syndrome as the first manifestation of a head and neck squamous cell carcinoma. Materials and methods:A 57-year-old man was admitted to the pulmonology department due to long-standing dyspnea along with bilateral pleural effusion and arthritis in knees, carpus and metacarpae of recent appearance. During his hospitalization he presents erythema and desquamation in the hands, auricular pavilions, knees and thighs; A minimal pericardial effusion was also observed. The autoimmunity analysis revealed positive antinuclear antibodies and Anti Ro positive, being the rest of the tests normal. The skin lesions are diagnosed as Acrokeratosis Paraneoplastica (Basex síndrome). The physical examination of the patient revealed the presence of a hard and adherent right cervical mass, not showing pharyngolaryngeal lesions or in other locations. A puncture with thick needle of cervical mass is performed, being the result of anatomopathological analysis squamous cell carcinoma. The mass is classified as cervical metastasis of unknown origin. Discussion:The systemic clinical manifestations by the metabolites of tumors are called paraneoplastic syndromes. The different metabolites produced can cause a wide range of symptoms, usually mediated by the toxic action of substances released by the tumor. They usually affect several organs and systems: endocrine, dermatological, ocular and osteoarticular. Paraneoplastic syndromes occur in 1 to 7.4% of all cancer patients, with presentation in infrequent head and neck neoplasms. Squamous cell carcinoma is the variant most frequently associated with this type of syndromes, also frequently occurring in neuroendocrine tumors, with a lower incidence in other types of tumors such as adenocarcinoma, adenoid cystic carcinoma, lymphomas and sarcomas. Basex Acrokeratosis Paraneoplastica was first described in 1965, being associated with carcinoma of the piriformis sinus. Clinically, it is characterized by erythematous desquamative skin patches with a predilection in the extremities and is the paraneoplastic syndrome that occurs most frequently in tumors of the larynx and hypopharynx. Conclusion:Physicians treating cancer patients should be able to differentiate paraneoplastic syndromes from other benign disorders; These syndromes can dominate the clinical picture of the patient leading to a diagnostic delay since this symptom eclipses the underlying oncological pathology. The paraneoplastic syndromes are important because they allow an early diagnosis and an adequate treatment of the patient's tumor
- Referencias
- Cómo citar
- Del mismo autor
- Métricas
Terán Muñoz, D., Rioja Peñaranda, E., Grijalba Uche, M., & Navazo Eguía, A. (2018). PARANEOPLASTIC SYNDROME IN PRIMARY HEAD AND NECK CANCER: A CASE REPORT. Revista ORL, 9(6), 3.22. https://doi.org/10.14201/orl.18289
Most read articles by the same author(s)
- Blanca Pilar Galindo Torres, Pablo Crespo Escudero, Danilo Terán Muñoz, Alicia Clemente García, Miguel Victor Grijalba Uche, Ana Isabel Navazo Eguía, Toxoplasmosis y Enfermedad por arañazo de gato. Diagnóstico diferencial de adenopatías laterocervicales. , Revista ORL: Segovia 2018
- Pablo Crespo Escudero, Elena Rioja Peñaranda, Cristina Cordero Civantos, Miguel Grijalba Uche, Ana Navazo Eguía, Abordaje “pull through” para tumores de suelo de boca que requieran RT adyuvante , Revista ORL: Segovia 2018
- Blanca Pilar Galindo Torres, Danilo Terán Muñoz, Pierre Ansorena González, Isabel Fernández De Alba, Maria Isabel Calle Cabanillas, Ana Isabel Navazo Eguía, Nuestro protocolo en el manejo de la tos crónica. , Revista ORL: Segovia 2018
- Pablo Crespo Escudero, Blanca Galindo Torres, Pierre Ansorena Gonzalez, Alicia Clemente García, Miguel Grijalba Uche, Ana Navazo Eguía, Uso del neuronavegador para biopsiar tumores de difícil acceso. , Revista ORL: Segovia 2018
- Pablo Crespo Escudero, Cristina Cordero Civantos, Alicia Clemente García, Miguel Grijalba Uche, Ana Navazo Eguía, Grapar vs No grapar en laringectomía total. , Revista ORL: Segovia 2018
- Elena Rioja Peñaranda, Cristina Cordero Civantos, Pierre Ansorena González, Alicia Clemente García, Maria Isabel Calle Cabanillas, Miguel Grijalba Uche, Paraganglioma parafaríngeo. Presentación de un caso , Revista ORL: SORIA 2019
- Danilo Terán Muñoz, Judith Pérez Sáez, María Isabel Calle Cabanillas, Miguel Grijalba Uche, Ana Navazo Eguía, ASYMPTOMATIC BASE OF THE TONGUE ADENOCARCINOMA , Revista ORL: Segovia 2018
- Blanca Pilar Galindo Torres, Arturo Rivas Salas, Danilo Terán Muñoz, Pablo Crespo Escudero, Cristina Cordero Civantos, Miguel Víctor Grijalba Uche, Patología salivar y sialoendoscopia. El inicio de una unidad. , Revista ORL: SORIA 2019
- Cristina Cordero Civantos, Maria Isabel Calle Cabanillas, Judit Pérez Sáez, Elena Rioja Peñaranda, Blanca Galindo Torres, Ana Isabel Navazo Eguía, Cuerpos extraños faringolaringeos infrecuentes en el anciano. Presentación de dos casos. , Revista ORL: Segovia 2018
- Danilo Terán Muñoz, Laura Álvarez Gómez, Elena Rioja Peñaranda, Fernando Gómez Sáez, María Luz Alonso Alvarez, Ana Navazo Eguía, Complicaciones post adenoamigdalectomía en pacientes pediátricos con SAHOS , Revista ORL: SORIA 2019
Downloads
Download data is not yet available.
+
−