From fiction to reality: Tissue regeneration in relation to Ransom Riggs´ «Tales of the Peculiar»
Abstract Ransom Riggs´ wealthy cannibals, deals with the history of the peculiar inhabitants of the village of Swampmuck, who were humble workers who lived on agriculture and possessed the amazing ability to complete regeneration of limbs, same that earned them their doom before the arrival of civilized and wealthy cannibals that were avid to acquire limbs for their sustenance. The cannibals´ proposal was very clear, they wanted to buy body parts from the inhabitants of the village, and as the self-perception of the farmers changed, and their desire to possess large amounts of money, gold and jewelry in return, had a devastating impact on the inhabitants of the village. In this article, the wealthy cannibals story is taken as a reference of contextualizing this fictional story to today’s society, trying to glimpse the potential impact on health care and prevention that could derive from a potential manipulation of stem cells to regenerate human tissues. Thus, we discuss the scope of this regenerative health medicine, given the chronic degenerative diseases epidemiological trends and at the same time, we explore the ethical implications that this could lead manipulation of stem cells is already an emerging experimental mode.
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Bergel S D, Células madre y libertad de investigación. Rev Bioet 2009(1):713-28.
Biehl JK, Russell B. Introduction to stem cell therapy. J Cardiovasc Nurs. 2009;24(2):98-105.
Consejo de Europa. Convenio relativo a los Derechos Humanos y la biomedicina. En: Couceiro A, Editor. Bioética para clínicos. Madrid: Ed. Triacastela; 1999.
Haas S, Velten L, Raffel S, Blaszkiewicz S, Huber W, Trumpp A, et al. Human haematopoietic stem cell differentiation follows a continuous waddington?like landscape. Exp Hematol. 2016;44(9):S77.
Hernández Ramírez P, Alfonso Simón A, Aparicio Suárez JL., Artaza Sanz H, Baganet Cobas A, Blanco Díaz Á, et al. Cuban experience with the therapeutic use of adult stem cells. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2011 Mar]; 27( 1 ):139-63.
Hernández Ramírez P. Medicina regenerativa y células madre. Mecanismos de acción de las células madre adultas. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2009; 25( 1 ): 1-15.
Kfoury C. Therapeutic cloning: promises and issues. Mcgill J Med. 2007;10(2):112-20.
O’brien T, Barry FP, editors. Stem cell therapy and regenerative medicine. Mayo Clin Proc. 2009;84(10):859-61.
Organización Mundial de la Salud. Comité de la Organización Mundial de la Salud. Serie de Informes Técnicos. Dieta, nutrición y prevención de enfermedades crónicas; 2003.
Riggs R, Davidson A. Cuentos extraños para niños peculiaes. Barcelona, España: Penguin Random House Grupo Editorial, S. A. U.; 2011.
Riggs R. El Hogar de Miss Peregrine Para Niños Peculiares. Ciudad de México: Editorial Planeta Mexicana SA de CV; 2016.
Torres Cosme JL. Clonación terapéutica: un dilema bioético actual. Perinatol Reprod Hum. [Internet]. 2005;19( 2 ): 71-6.
Vega SL, Liu E, Arvind V, Bushman J, Sung H-J, Becker ML, et al. High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation. Exp Cell Res. 2017;351(1):11-23.
Vignolo J, Vacarezza M, Álvarez C, Sosa A. Niveles de atención, de prevención y atención primaria de la salud. Arch Med Int [Internet]. 2011; 33( 1 ): 7-11.
Yawn BP, Buchanan GR, Afenyi Annan AN, Ballas SK, Hassell KL, James AH, et al. Management of Sickle Cell DiseaseSummary of the 2014 Evidence-Based Report by Expert Panel Members. JAMA. 2014;312(10):1033-48.
Martínez Gómez, C. O., & Méndez Domínguez, N. (2017). From fiction to reality: Tissue regeneration in relation to Ransom Riggs´ «Tales of the Peculiar». Journal of Medicine and Movies, 13(3), 135–139. Retrieved from https://revistas.usal.es/cinco/index.php/medicina_y_cine/article/view/16981
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