Mediastinal paraganglioma detected by 111in-Pentetreotide scintigraphy and SPECT/TC. A case report
Abstract Introduction: Mediastinal paragangliomas are low incidence tumors that arise from neural crest. Its diferential diagnosis include several malignant diseases, so its correct characterization is mandatory for an adecuate therapeutic management. 111In-Pentetreotide scintigraphy/SPECT-CT can detect paraganglioma, mainly in those cases of atypical or unsuspected location, and may have a significant role in follow-up of those patients diagnosed with multifocal and familiar paraganglioma. Case: Here we report a case of an extremely rare middle mediastinal paraganglioma, detected by scintigraphy and SPECT-CT with 111In-Pentetreotide in a patient diagnosed of multifocal and family history of paraganglioma. Surgery was carried out by median sternotomy and extracorporeal circulation. The pathological examination of the surgical specimen showed a para-aortic low-grade tumor, positive for chromogranin and synaptophysin, cytokeratin AE1-AE3 negative and Ki67 lower than 5%, compatible with paraganglioma. Currently, the patient is tumor free, under clinical monitoring. Conclusions: 111In- Pentetreotide scan proved to be a helpful diagnostic method because of its potential to explore full body, so It allows us to locate unsuspected and atypical location paragangliomas. This finding suggests that patients diagnosed with multifocal head and neck paraganglioma should undergo periodical follow-up with 111In-Pentetreotide scan to detect unsuspected paraganglioma.
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Bano G, Sennik D, Kenchaiah M, Kyaw Y, Snape K, Tripathi V, et al. A case of co-existing paraganglioma and thymoma. Springerplus. 2015;21(4):632. https://doi.org/10.1186/s40064-015-1269-z - PMid:26543766 PMCid:PMC4628025
Bustillo A, Telischi F, Weed D, Civantos F, Angeli S, Serafini A, et al. Octreotide scintigraphy in the head and neck. Laryngoscope. 2004; 114: 434-40. https://doi.org/10.1097/00005537-200403000-00010 - PMid:15091215
Castillo-Berrio C, Castrillón M, Zelaya F, Ruíz D, Loira F, Nogueiras JM, et al. (111)In-octreotide SPECT-CT in head and neck paragangliomas. Rev Esp Med Nucl Imagen Mol. 2015;34(5):321-4. https://doi.org/10.1016/j.remn.2015.02.007 - PMid:25858499
Därr R, Lenders JW, Hofbauer LC, Naumann B, Bornstein SR, Eisenhofer G. Pheochromocytoma-update on disease management. Ther Adv Endocrinol Metab. 2012;3:11-26. https://doi.org/10.1177/2042018812437356 - PMid:23148191 PMCid:PMC3474647
Feijoo Cano C, Carranza Martinez JM, Rivera Rodríguez MI, Vázquez Berges I, Herrando Medrano M, Marco Luque MA. Tumores del cuerpo carotídeo. Experiencia en 22 a-os y protocolo de seguimiento y despistaje familiar. Angiologia. 2012;64:155–60. https://doi.org/10.1016/j.angio.2012.02.004
Mehta CK, Gillespie CT, Lin X, Yeldandi A, DeCamp M, Bharat A. Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor. Ann Thorac Surg. 2015;100(2):702-5. https://doi.org/10.1016/j.athoracsur.2014.09.068 - PMid:26234842
Schmidt M, Fischer E, Dietlein M, Michel O, Weber K, Moka D, et al. Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas. Eur J Nucl Med Mol Imaging. 2002;29(12):1571-80. https://doi.org/10.1007/s00259-002-0939-6 - PMid:12458390
Shibahara J, Goto A, Niki T, Tanaka M, Nakajima J, Fukayama M. Primary pulmonary paraganglioma: report of a functioning case with inmunohistochemical and ultrastructural study. Am J Surg Pathol 2004;28:825-9. https://doi.org/10.1097/01.pas.0000116832.81882.0b - PMid:15166677
Tamayo P, Ruano R, Mu-oz A. Diagnóstico y control evolutivo de los paragangliomas de cabeza y cuello. Aportaciones de la medicina nuclear. Acta Otorrinolaringol Esp. 2009;60:68–75.
Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG (Eds.). WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart. IARC: Lyon, 2015.
Bustillo A, Telischi F, Weed D, Civantos F, Angeli S, Serafini A, et al. Octreotide scintigraphy in the head and neck. Laryngoscope. 2004; 114: 434-40. https://doi.org/10.1097/00005537-200403000-00010 - PMid:15091215
Castillo-Berrio C, Castrillón M, Zelaya F, Ruíz D, Loira F, Nogueiras JM, et al. (111)In-octreotide SPECT-CT in head and neck paragangliomas. Rev Esp Med Nucl Imagen Mol. 2015;34(5):321-4. https://doi.org/10.1016/j.remn.2015.02.007 - PMid:25858499
Därr R, Lenders JW, Hofbauer LC, Naumann B, Bornstein SR, Eisenhofer G. Pheochromocytoma-update on disease management. Ther Adv Endocrinol Metab. 2012;3:11-26. https://doi.org/10.1177/2042018812437356 - PMid:23148191 PMCid:PMC3474647
Feijoo Cano C, Carranza Martinez JM, Rivera Rodríguez MI, Vázquez Berges I, Herrando Medrano M, Marco Luque MA. Tumores del cuerpo carotídeo. Experiencia en 22 a-os y protocolo de seguimiento y despistaje familiar. Angiologia. 2012;64:155–60. https://doi.org/10.1016/j.angio.2012.02.004
Mehta CK, Gillespie CT, Lin X, Yeldandi A, DeCamp M, Bharat A. Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor. Ann Thorac Surg. 2015;100(2):702-5. https://doi.org/10.1016/j.athoracsur.2014.09.068 - PMid:26234842
Schmidt M, Fischer E, Dietlein M, Michel O, Weber K, Moka D, et al. Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas. Eur J Nucl Med Mol Imaging. 2002;29(12):1571-80. https://doi.org/10.1007/s00259-002-0939-6 - PMid:12458390
Shibahara J, Goto A, Niki T, Tanaka M, Nakajima J, Fukayama M. Primary pulmonary paraganglioma: report of a functioning case with inmunohistochemical and ultrastructural study. Am J Surg Pathol 2004;28:825-9. https://doi.org/10.1097/01.pas.0000116832.81882.0b - PMid:15166677
Tamayo P, Ruano R, Mu-oz A. Diagnóstico y control evolutivo de los paragangliomas de cabeza y cuello. Aportaciones de la medicina nuclear. Acta Otorrinolaringol Esp. 2009;60:68–75.
Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG (Eds.). WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart. IARC: Lyon, 2015.
Díaz-González, L. G., Pérez-López, B., Franco-Rodríguez, Y., Muñoz-Herrera, Ángel, & Tamayo-Alonso, P. (2017). Mediastinal paraganglioma detected by 111in-Pentetreotide scintigraphy and SPECT/TC. A case report. Revista ORL, 8(4), 249–252. https://doi.org/10.14201/orl.15783
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