Vasovagal syncope and head and neck tumors. Retrospective study
Abstract Introduction and objectives: Syncope, although rare, can be a manifestation of head and neck tumors. Three clinical pictures have been described: Carotid sinus syndrome, Neuralgia – glossopharyngeal asystole, and Parapharyngeal space syndrome. Our objective was to define the clinical characteristics of these syncodes in our hospital. Methods: Retrospective descriptive study of patients with head and neck tumors who presented related syncope, diagnosed between January 2012 and April 2022 at the Marqués de Valdecilla University Hospital. Results: Five patients with head and neck cancer showed syncope related to their pathology. There were two women and three men, with an average age of 70 years. All had involvement of the parapharyngeal space. Two presented syncope before diagnosis and three after. Conclusions: Syncope should be considered in the differential diagnosis of head and neck tumors, especially after ruling out cardiovascular pathology. In patients already diagnosed, it may indicate involvement of the parapharyngeal space.
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Sutton R. Carotid sinus syndrome: Progress in understanding and management. Glob Cardiol Sci Pract. 2014; 2014(2):18. https://doi.org/10.5339/gcsp.2014.18
Whitman MA, Jefferson A, Pincelli T, Sanghavi DK. Case of vago-glossopharyngeal neuralgia secondary to metastatic oropharyngeal cancer. BMJ Case Rep. junio de 2020; 13(6):e232820. https://doi.org/10.1136/bcr-2019-232820
Jannone Pedro N, Domingo Monge FJ, Lominchar Espada J. Neuralgia glosofaríngea asociada a síncopes y secundaria a carcinoma de cuello. Rev Neurol. 2018; 67(09):371. https://doi.org/10.33588/rn.6709.2018104
Nakahira M, Nakatani H, Takeda T. Syncope as a Sign of Occult Malignant Recurrence in the Retropharyngeal and Parapharyngeal Space: CT and MR Imaging Findings in Four Cases. AJNR Am J Neuroradiol. 2002; 23:1257-60.
Minkara A, Dhanda-Patil R, Patil Y. Syncope caused by a pleomorphic adenoma: Case report and literature review. Ear Nose Throat J. 2018; 97: E23-E26. https://doi.org/10.1177/0145561318097001-206
Bozyel S, Güler TE, Çelik M, Dalgıç N, Şipal A, Yalnız A. Cardioneuroablation for treatment of carotid sinus syndrome secondary to oropharyngeal squamous cell cancer. J Cardiovasc Electrophysiol. 2023; 34:1305-1309. https://doi.org/10.1111/jce.15895
Van Dijk JG, Van Rossum IA, Thijs RD. The pathophysiology of vasovagal syncope: Novel insights. Auton Neurosci. 2021; 236:102899. https://doi.org/10.1016/j.autneu.2021.102899
Toscano M, Cristina S, Alves AR. Carotid Sinus Syndrome in a Patient with Head and Neck Cancer: A Case Report. Cureus. 2020; 12:e7042. https://doi.org/10.7759/cureus.7042
Voboril GR, Rotondaro JC, Rosati M, Guerrieri VC, Martinez YP, Martinenghi N, et al. Casuística síndrome del seno carotídeo asociado a linfoma B cervical. Medicina (B. Aires). 2022; 82:300-303.
Sutton R. Carotid sinus syndrome: Progress in understanding and management. Glob Cardiol Sci Pract. 2014; 2014(2):18. https://doi.org/10.5339/gcsp.2014.18
Whitman MA, Jefferson A, Pincelli T, Sanghavi DK. Case of vago-glossopharyngeal neuralgia secondary to metastatic oropharyngeal cancer. BMJ Case Rep. junio de 2020; 13(6):e232820. https://doi.org/10.1136/bcr-2019-232820
Jannone Pedro N, Domingo Monge FJ, Lominchar Espada J. Neuralgia glosofaríngea asociada a síncopes y secundaria a carcinoma de cuello. Rev Neurol. 2018; 67(09):371. https://doi.org/10.33588/rn.6709.2018104
Nakahira M, Nakatani H, Takeda T. Syncope as a Sign of Occult Malignant Recurrence in the Retropharyngeal and Parapharyngeal Space: CT and MR Imaging Findings in Four Cases. AJNR Am J Neuroradiol. 2002; 23:1257-60.
Minkara A, Dhanda-Patil R, Patil Y. Syncope caused by a pleomorphic adenoma: Case report and literature review. Ear Nose Throat J. 2018; 97: E23-E26. https://doi.org/10.1177/0145561318097001-206
Bozyel S, Güler TE, Çelik M, Dalgıç N, Şipal A, Yalnız A. Cardioneuroablation for treatment of carotid sinus syndrome secondary to oropharyngeal squamous cell cancer. J Cardiovasc Electrophysiol. 2023; 34:1305-1309. https://doi.org/10.1111/jce.15895
Martínez-Camerano, A., Morales-Angulo, C., Veiga-Alonso, A., & Fernandez-Enseñat, J. (2025). Vasovagal syncope and head and neck tumors. Retrospective study. Revista ORL, 16(2), e32444. https://doi.org/10.14201/orl.32444
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