Early alterations of oropharyngeal dysphagia in bulbar and spinal amyotrophic lateral sclerosis. Cases and control study
Abstract Introduction and objective: The objective of the study is to establish the early alterations of oropharyngeal dysphagia (OD) in bulbar ALS and spinal ALS, to verify possible differences between both groups and to know the percentage of patients with ALS who require dietary adaptations after their first visit to the otorhinolaryngologist (ENT). Method: Retrospective study of 10 patients with bulbar ALS and 10 patients with spinal ALS from our hospital, evaluated by ENT at the recent diagnosis of ALS. Variables collected: demographic (age, sex) and clinical, including early alterations in the swallowing test under fiberoendoscopy (FEES) and the type of diet of each patient; and comparison of the findings between both groups. Results: Of 20 patients (median age= 68 years), 50 % presented spinal ALS and 50 % presented bulbar ALS. The swallowing test demonstrated incompetence in the propulsion of the bolus (15 % of patients) and pharyngolaryngeal residue (40 % of patients). Statistically significant differences are evident between both groups in the penetrations and aspirations observed under FEES (p<0.05) and in the need for dietary adaptations after ENT evaluation, predominating in bulbar ALS. Discussion: We found significant differences in OD between bulbar and spinal ALS, describing a greater alteration in patients diagnosed with bulbar ALS. Conclusions: The fundamental role of the otorhinolaryngologist lies in the early detection of OD in patients with ALS, preventing and/or reducing potential respiratory complications derived from it.
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Alcalde Muñoz S, Ricote Belinchón M (dir.), Rodríguez R. Guía de disfagia: manejo de la disfagia en Atención Primaria. Semergen. 2019. España. ISBN 978-84-9449966-8-4.
Masrori P, Van Damme P. Amyotrophic lateral sclerosis: a clinical review. Eur J Neurol. 2020 Oct;27(10):1918-1929. https://doi.org/10.1111/ene.14393. Epub 2020 Jul 7. PMID: 32526057; PMCID: PMC7540334.
Zapata-Zapata CH, Franco Dager E, Solano-Atehortúa JM, Ahunca-Velásquez LF. Esclerosis lateral amiotrófica; actualización. Iatreia.2016 Abr-Jun;29(2):194-205. https://doi.org/10.17533/udea.iatreia.v29n2a08
Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. Declaración de la iniciativa STROBE (Strengthening the Reporting of Observational Studies in Epidemiology): directrices para la comunicación de estudios observacionales. Revista Española de Salud Pública [Internet]. junio de 2008 [citado 14 de septiembre de 2024];82(3):251-9. Disponible en: https://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S1135-57272008000300002&lng=es&nrm=iso&tlng=es
Costa JB, Pereira D, Duarte D, Viana M. Otolaryngologist's role in the diagnosis of amyotrophic lateral sclerosis. BMJ Case Rep. 2021 Feb 23;14(2):e234504. https://doi.org/10.1136/bcr-2020-234504. PMID: 33622737; PMCID: PMC7907849.
Orellana Zambrano MD, Candelo E, Rutt AL. The Role of the Otolaryngologist in Early Recognition of Patients With ALS: A Case Report. Ear Nose Throat J. 2022 Nov. https://doi.org/10.1177/01455613221120731. Epub ahead of print. PMID: 36358031.
Tsunoda K, Takazawa M, Chong T, Morita Y. Slow, slurred speech as an initial complaint in amyotrophic lateral sclerosis. Auris Nasus Larynx. 2019 Apr;46(2):193-195. https://doi.org/10.1016/j.anl.2018.07.007. Epub 2018 Aug 16. PMID: 30120006.
Fattori B, Siciliano G, Mancini V, Bastiani L, Bongioanni P, Caldarazzo Ienco E, Barillari MR, Romeo SO, Nacci A. Dysphagia in Amyotrophic Lateral Sclerosis: Relationships between disease progression and Fiberoptic Endoscopic Evaluation of Swallowing. Auris Nasus Larynx. 2017 Jun;44(3):306-312. https://doi.org/10.1016/j.anl.2016.07.002. Epub 2016 Aug 25. PMID: 27569290.
Harrison L, Wills A, Beasley N. Diagnosing amyotrophic lateral sclerosis (ALS) in ENT. Clin Otolaryngol. 2013 Dec;38(6):564-5. https://doi.org/10.1111/coa.12186. PMID: 25741568.
Galvin M, Ryan P, Maguire S, Heverin M, Madden C, Vajda A, Normand C, Hardiman O. The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs. PLoS One. 2017 Jun 22;12(6):e0179796. https://doi.org/10.1371/journal.pone.0179796. PMID: 28640860; PMCID: PMC5480998.
Masrori P, Van Damme P. Amyotrophic lateral sclerosis: a clinical review. Eur J Neurol. 2020 Oct;27(10):1918-1929. https://doi.org/10.1111/ene.14393. Epub 2020 Jul 7. PMID: 32526057; PMCID: PMC7540334.
Zapata-Zapata CH, Franco Dager E, Solano-Atehortúa JM, Ahunca-Velásquez LF. Esclerosis lateral amiotrófica; actualización. Iatreia.2016 Abr-Jun;29(2):194-205. https://doi.org/10.17533/udea.iatreia.v29n2a08
Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. Declaración de la iniciativa STROBE (Strengthening the Reporting of Observational Studies in Epidemiology): directrices para la comunicación de estudios observacionales. Revista Española de Salud Pública [Internet]. junio de 2008 [citado 14 de septiembre de 2024];82(3):251-9. Disponible en: https://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S1135-57272008000300002&lng=es&nrm=iso&tlng=es
Costa JB, Pereira D, Duarte D, Viana M. Otolaryngologist's role in the diagnosis of amyotrophic lateral sclerosis. BMJ Case Rep. 2021 Feb 23;14(2):e234504. https://doi.org/10.1136/bcr-2020-234504. PMID: 33622737; PMCID: PMC7907849.
Orellana Zambrano MD, Candelo E, Rutt AL. The Role of the Otolaryngologist in Early Recognition of Patients With ALS: A Case Report. Ear Nose Throat J. 2022 Nov. https://doi.org/10.1177/01455613221120731. Epub ahead of print. PMID: 36358031.
Tsunoda K, Takazawa M, Chong T, Morita Y. Slow, slurred speech as an initial complaint in amyotrophic lateral sclerosis. Auris Nasus Larynx. 2019 Apr;46(2):193-195. https://doi.org/10.1016/j.anl.2018.07.007. Epub 2018 Aug 16. PMID: 30120006.
Fattori B, Siciliano G, Mancini V, Bastiani L, Bongioanni P, Caldarazzo Ienco E, Barillari MR, Romeo SO, Nacci A. Dysphagia in Amyotrophic Lateral Sclerosis: Relationships between disease progression and Fiberoptic Endoscopic Evaluation of Swallowing. Auris Nasus Larynx. 2017 Jun;44(3):306-312. https://doi.org/10.1016/j.anl.2016.07.002. Epub 2016 Aug 25. PMID: 27569290.
Harrison L, Wills A, Beasley N. Diagnosing amyotrophic lateral sclerosis (ALS) in ENT. Clin Otolaryngol. 2013 Dec;38(6):564-5. https://doi.org/10.1111/coa.12186. PMID: 25741568.
Galvin M, Ryan P, Maguire S, Heverin M, Madden C, Vajda A, Normand C, Hardiman O. The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs. PLoS One. 2017 Jun 22;12(6):e0179796. https://doi.org/10.1371/journal.pone.0179796. PMID: 28640860; PMCID: PMC5480998.
Martín-García, S., Fernández-Nava, M. J., De-Rodrigo-Tobías, E., Tamayo-Esquinas, A. J., Sánchez-Jara-Sánchez, J. L., & Martín-Hernández, G. (2024). Early alterations of oropharyngeal dysphagia in bulbar and spinal amyotrophic lateral sclerosis. Cases and control study. Revista ORL, 16(1), e32169. https://doi.org/10.14201/orl.32169
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