Incidence and clinical and epidemiological characteristic of nasopharynx carcinoma in Cantabria in 2014
Abstract Introduction and Objective: The objective of this study was to describe the clinic-epidemiological characteristics of the nasopharyngeal carcinoma in Cantabria (Spain) and to compare it with previous studies performed. Material and methods: A retrospective study of nasopharyngeal carcinomas diagnosed in Marqués de Valdecilla Hospital (Santander, Cantabria, Spain) between 2004 and 2015 was made, determining the following variables: age, occupation, toxics, outcome symptoms, treatment and clinical evolution. Results: 45 patients with ages range between 35 and 85 were diagnosed of nasopharyngeal carcinoma, with an incidence of 0,71/100000H/year. 38 were men (84,5%) and 7 were women (15,6%). The fifties decade was the most frequent period of diagnosis. Otological symptoms were the main clinical outcome (40%), followed by cervical adenopathy (26,6%). Undifferentiated carcinoma was the most common histological type (68,9%), being diagnosed in advanced stages. Conclusions: Nasopharyngeal carcinoma is an uncommon tumour in Cantabria being more frequent in males in their fifties. Its clinical presentation, often nonspecific, results in advanced stages diagnose. The most common histological type (undifferentiated carcinoma).
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Rassekh CH, Rady PL, Arany I, Tyring SK, Knudsen S, Calhoun KH et al. Combined Epstein-Barr virus and human papillomavirus infection in nasopharyngeal carcinoma. Laryngoscope. 1998;108:362-7.
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Sanguineti G1, Geara FB, Garden AS, Tucker SL, Ang KK, Morrison WH et al. Carcinoma of the nasopharynx treated by radiotherapy alone. Determinants of local and regional control. Int J Radiat ncol Biol Phys. 1997;37:985-96.
https://doi.org/10.1016/S0360-3016(97)00104-1
Simons MJ, Chan SH, Wee GB, Shanmugaratnam K, Goh EH, Ho JH et al Nasopharyngeal carcinoma and histocompatibility antigens. IARC Sci Publ. 1978;20:271-82.
Simons MJ, Wee GB, Singh D, Dharmalingham S, Yong NK, Chau JC et al. Immunogenetic aspects of nasopharyngeal carcinoma. V. Confirmation of a Chinese-related HLA profile [A2, Singapore 2] associated with an increased risk in Chinese for nasopharyngeal carcinoma. Natl Cancer Inst Monogr. 1977;47:147-51.
PMid:613233
Yu MC: Nasopharyngeal carcinom. Epidemiology and dietary factors, IARC Sci Publ 1991;105:39-47.
https://doi.org/10.1200/JCO.1998.16.4.1310
PMid:9552031
Edge SB, Comptom CC. The AJCC cancer staging manual. 8th ed. Springer; 2009.
Ferlay J, Bray F, Pisani P, Parkin DM. Globocan 2002. Cancer Incidence, mortality and prevalence worlwide IARC. CancerBase N, versión 2.0. Lyon: IARC Press 2004. Disponible en: https://gco.iarc.fr/. [Citado el 05/01/2019].
Ferlito A, Elsheikh MN, Manni JJ, Rinaldo A. Paraneoplastic syndromes in patients with primary head and neck cancer. Eur Arch Otorhinolaryngol. 2007;264:211–22.
https://doi.org/10.1007/s00405-006-0217-5
PMid:17206403
Harding U, Nielsen H, Daugaard S. Human papillomavirus types 11 and 16 detected in nasopharyngeal carcinoma by the polimerase chain reaction. Laryngoscope. 1994;104:99-102.
Huang HY, Wilkie DJ, Schubert MM, Ting LL. Symptom profile of nasopharyngeal cancer patients during radiation therapy Cancer Pract. 2000;8:274-81.
https://doi.org/10.1046/j.1523-5394.2000.86007.x
https://doi.org/10.1111/j.1523-5394.2000.86007.pp.x
PMid:11898144
Iannessi A, Ouvrier MJ, Thariat J, Marcy PY. Imaging in head and neck cancers. Bull Cancer. 2014 1;101:469-80.
ICANE. Población de Cantabria 2014 Disponible en: https://www.icane.es/. [Citado el 23 Abril 2015].
Indudharan R, Valuyeetham M, Kannan T, Sidek DS. Nasopharyngeal carcinoma: clinical trends. J Otol Rhinl Laryngol. 1997;111:724-9.
https://doi.org/10.1017/S0022215100138460
Lester D. Thompson R. Update on Nasopharyngeal Carcinoma. Head Neck Pathol. 2007;1:81–6.
https://doi.org/10.1007/s12105-007-0012-7
PMid:20614287 PMCid:PMC2807508
Lin JC1, Wang WY, Chen KY, Wei YH, Liang WM, Jan JS et al. Quantification of plasma Epstein Barr virus DNA in patients with advanced nasopharyngeal carcinoma, N Engl J Med. 2004;350: 2461-70.
https://doi.org/10.1056/NEJMoa032260
PMid:15190138
Mills S. Metatastatic undifferentiated carcinoma, lymphoepithelioma type. Arch Otolaryngol. 1982;108: 258-60.
PMid:7073600
Morales-Angulo C, Megía López R, Rubio Suárez A, Bezos. Capelastegui JT, Rama J. Diagnóstico precoz del carcinoma de nasofaringe. An Otorrinolaringol Ibero Am. 2001;28:317-23.
PMid:11455888
Morales-Angulo C, Megía López R, Rubio Suárez A, Rivera Herrero F, Rama J. Carcinoma de Nasofaringe en Cantabria. Acta Otorrinolaring Esp. 1999;50:381-86.
PMid:10491475
Murono S1, Yoshizaki T, Tanaka S, Takeshita H, Park CS, Furukawa M. Detection of Epstein Barr virus in nasopharyngeal carcinoma by in situ hybridation and polymerase chain reaction. Laryngoscope 1997;107:523-6.
https://doi.org/10.1097/00005537-199704000-00017
Nam JM, McLaughlin JK, Blot WJ. Cigarette smoking, alcohol, and nasopharyngeal carcinoma: a case-control study among U.S. whites. Natl Cancer Inst. 1992;84:619-22.
https://doi.org/10.1093/jnci/84.8.619
Pensak ML. Otolaryngology cases, Nasopharyngeal cancer.1º ed. USA. Thieme; 2010.
Poon PY, T Sang VH, Munk PL. Tumour extent and T stage of nasopharyngeal carcinoma. A comparison of magnetic resonance imaging and computed tomographic findings, Can Assoc Radiol J. 2000;51:287-95.
PMid:11077556
Rassekh CH, Rady PL, Arany I, Tyring SK, Knudsen S, Calhoun KH et al. Combined Epstein-Barr virus and human papillomavirus infection in nasopharyngeal carcinoma. Laryngoscope. 1998;108:362-7.
https://doi.org/10.1097/00005537-199803000-00010
PMid:9504608
Sanguineti G1, Geara FB, Garden AS, Tucker SL, Ang KK, Morrison WH et al. Carcinoma of the nasopharynx treated by radiotherapy alone. Determinants of local and regional control. Int J Radiat ncol Biol Phys. 1997;37:985-96.
https://doi.org/10.1016/S0360-3016(97)00104-1
Simons MJ, Chan SH, Wee GB, Shanmugaratnam K, Goh EH, Ho JH et al Nasopharyngeal carcinoma and histocompatibility antigens. IARC Sci Publ. 1978;20:271-82.
Simons MJ, Wee GB, Singh D, Dharmalingham S, Yong NK, Chau JC et al. Immunogenetic aspects of nasopharyngeal carcinoma. V. Confirmation of a Chinese-related HLA profile [A2, Singapore 2] associated with an increased risk in Chinese for nasopharyngeal carcinoma. Natl Cancer Inst Monogr. 1977;47:147-51.
PMid:613233
Yu MC: Nasopharyngeal carcinom. Epidemiology and dietary factors, IARC Sci Publ 1991;105:39-47.
Río-González, G., Corriols-Noval, P., Viana-Cora, A., Castillo-Ledesma, N., López-Simón, E., & Morales-Angulo, C. (2019). Incidence and clinical and epidemiological characteristic of nasopharynx carcinoma in Cantabria in 2014. Revista ORL, 10(3), 171–180. https://doi.org/10.14201/orl.19707
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