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Myelitis and anti-Yo antibodies: a paraneoplastic syndrome associated with nasopharyngeal carcinoma detected by positron emission tomography. A case report

https://doi.org/10.14201/orl.32012

Abstract

Introduction and objective: Paraneoplastic syndromes (PS) associated with nasopharyngeal carcinoma (NC) are very rare. We described a patient who presented with a paraneoplastic mielitis associated with anti-Yo antibodies and NC. Description: A 70 year-old previously healthy man presented with a progressive gait disorder. The diagnosis work up demonstrated both the presence of anti-Yo antibodies together with a NC, suspected by positron emission tomography (PET-CT). Despite prompt treatment with steroids, gammaglobulins and a satisfactory tumour therapy, partial neurological symptomathology persisted. Conclusions: Although rare, clinicians should consider the possibility of paraneoplastic aetiology when attending patients with NC presenting with subacute neurological symptoms.
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Riancho, J., Rodríguez-Rodríguez, E., Martínez-Camerano, A., & Morales-Angulo, C. (2024). Myelitis and anti-Yo antibodies: a paraneoplastic syndrome associated with nasopharyngeal carcinoma detected by positron emission tomography. A case report. Revista ORL, 16(1), e32012. https://doi.org/10.14201/orl.32012

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