Detection of Renal Damage Risk in Smokers
Abstract The etiology of various types of cancer, in addition to pathologies related to the cardiovascular and respiratory system, lies in the consumption of tobacco. Today, new studies suggest that tobacco causes kidney damage that can degenerate into chronic long-term kidney failure. However, the parameters used in clinic to detect renal damage, such as plasma creatinine, are not useful to show dysfunction. Therefore, the most innovative diagnostic methods include urinary biomarkers of early renal damage, which would prevent the progression of kidney disease. On the other hand, based on previous studies of our laboratory, the concept of acquired predisposition to kidney damage has been developed, as well as the existence of urinary biomarkers associated with this condition. Our goal is to study whether certain predisposition biomarkers are able to detect among smokers those who are predisposed to suffer renal damage. Our results show that some of these biomarkers are excreted in urine significantly higher in smokers than in non-smokers. The increased excretion of these biomarkers could be related to a predisposition of smoking individuals to suffer renal damage, a key aspect to be considered in clinical practice.
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Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol. mayo de 2010; 28(5):436-440.
Examen de creatinina en la sangre: MedlinePlus enciclopedia médica [Internet]. [citado 26 de junio de 2019]. Disponible en: https://medlineplus.gov/spanish/ency/article/003475.htm.
OMS | Tabaquismo [Internet]. WHO. [citado 20 de mayo de 2019]. Disponible en: http://www.who.int/topics/tobacco/es/.
Perjuicios por fumar cigarrillos y beneficios para la salud al dejar el hábito [Internet]. National Cancer Institute; 2018. [citado 17 de junio de 2019]. Disponible en: https://www.cancer.gov/espanol/cancer/causas-prevencion/riesgo/tabaco/hoja-informativa-dejar-de-fumar.
Pickering JW, Endre ZH. The Metamorphosis of Acute Renal Failure to Acute Kidney Injury. Basic Nephrology and Acute Kidney Injury [Internet]. 2 de marzo de 2012. [citado 20 de mayo de 2019]. Disponible en: https://www.intechopen.com/books/basic-nephrology-and-acute-kidney-injury/the-metamorphosis-of-acute-renal-failure-to-acute-kidney-injury.
Pinto-Sietsma SJ, Mulder J, Janssen WM, Hillege HL, de Zeeuw D, de Jong PE. Smoking is related to albuminuria and abnormal renal function in nondiabetic persons. Ann Intern Med. 17 de octubre de 2000; 133(8):585-591.
Products C for T. Harmful and Potentially Harmful Constituents (HPHCs). FDA [Internet]. 23 de abril de 2019. [citado 20 de mayo de 2019]. Disponible en: /tobacco-products/products-ingredients-components/harmful-and-potentially-harmful-constituents-hphcs.
Products C for T. Tobacco Products [Internet]. FDA. 2019. [citado 20 de mayo de 2019]. Disponible en: /tobacco-products.
pronefro_3_clase10.pdf [Internet]. [citado 20 de mayo de 2019]. Disponible en: http://san.org.ar/pronefro_3/mod_I/clase_X/pronefro_3_clase10.pdf.
PUESTA A PUNTO DE UN MÉTODO ANALÍTICO. DETERMINACIÓN DE CREATININA EN ORINA BASADO EN LA REACCIÓN CINÉTICA DE JAFFE.pdf [Internet]. [citado 18 de junio de 2019]. Disponible en: https://riull.ull.es/xmlui/bitstream/handle/915/5030/PUESTA%20A%20PUNTO%20DE%20UN%20METODO%20ANALITICO.%20DETERMINACION%20DE%20CREATININA%20EN%20ORINA%20BASADO%20EN%20LA%20REACCION%20CINETICA%20DE%20JAFFE.pdf?sequence=1&isAllowed=y
Sirota JC, Klawitter J, Edelstein CL. Biomarkers of acute kidney injury. J Toxicol. 2011; 2011:1-10.
Tascón, J., Hernández-Sánchez, M. T., G. Casanova, A., Vicente-Vicente, L., Morales, A. I., & Prieto, M. (2021). Detection of Renal Damage Risk in Smokers. FarmaJournal, 6(2), 49–62. https://doi.org/10.14201/fj2021624962
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