Bazex syndrome related to oropharyngeal carcinoma. Case report
Abstract Introduction and objective: Bazex syndrome is an infrequent paraneoplastic syndrome that is related to an upper aerodigestive epidermoid carcinoma. A case of characteristic Bazex syndrome is presented to contribute to an early diagnosis of the associated underlying tumor pathology. Case description: 57-year-old male, smoker and regular drinker, presented with a cervical mass associated with scaly and violaceous eczema on hands, feet, ears and knees. After examination and complementary tests, the diagnosis of T2N3M0 tonsillar squamous cell carcinoma and paraneoplastic syndrome was established. Conclusions: Oropharyngeal carcinoma is one of the most frequent tumors associated with Bazex syndrome. Therefore, if we observe these skin lesions, we should always rule out oncological pathology at that level.
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Bazex A, Salvador R, Dupré A, Christol B. Syndrome paranéoplasique à type d'hyperkératose des extremités. Guérison après le traitement de l'épithelioma laryngé. Bull Soc Fr Dermatol Syphiligr 1965;72:182.
Bolognia J, Brewer Y, Cooper D. Bazex syndrome (acrokeratosis paraneoplastica). An analytic review. Medicine (Baltimore). 1991;70:269-80. - https://doi.org/10.1097/00005792-199107000-00004
Fasanmade A, Farrell K, Perkins CS. Bazex syndrome (acrokeratosis paraneoplastica): persistence of cutaneous lesions after successful treatment of an associated oropharyngeal neoplasm. Br J Oral Maxillofac Surg. 2009;47:138-9. - https://doi.org/10.1016/j.bjoms.2008.07.190
Hempen A, Samartzis EP, Kamarachev J, Fink D, Dedes KJ. Acrokeratosis paraneoplastica in serous ovarian carcinoma: case report. BMC Cancer. 2015;15:507. - https://doi.org/10.1186/s12885-015-1527-z
Poligone B, Christensen SR, Lazova R, Heald PW. Bazex syndrome (acrokeratosis paraneoplastica). Lancet. 2007;369(9560):530. - https://doi.org/10.1016/S0140-6736(07)60240-2
Silva JA, Mesquita KC, Igreja AC, Lucas IC, Freitas AF, Oliveira SM et al. Paraneoplastic cutaneous manifestations: concepts and updates. An. Bras. Dermatol.2013;88(1):9-22. - https://doi.org/10.1590/S0365-05962013000100001
Squires B, Daveluy SD, Joiner MC, Hurst N, Bishop M, Miller SR. Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma. Case Rep Dermatol Med. 2016;2016:7137691. - https://doi.org/10.1155/2016/7137691
Villares Soriano J, Vázquez Barro C, Martínez Vidal J. Acroqueratosis de Bazex como síndrome paraneoplásico. Acta Otorrinolaringol Esp. 2014;65:138-9. - https://doi.org/10.1016/j.otorri.2012.10.003
Bolognia J, Brewer Y, Cooper D. Bazex syndrome (acrokeratosis paraneoplastica). An analytic review. Medicine (Baltimore). 1991;70:269-80. - https://doi.org/10.1097/00005792-199107000-00004
Fasanmade A, Farrell K, Perkins CS. Bazex syndrome (acrokeratosis paraneoplastica): persistence of cutaneous lesions after successful treatment of an associated oropharyngeal neoplasm. Br J Oral Maxillofac Surg. 2009;47:138-9. - https://doi.org/10.1016/j.bjoms.2008.07.190
Hempen A, Samartzis EP, Kamarachev J, Fink D, Dedes KJ. Acrokeratosis paraneoplastica in serous ovarian carcinoma: case report. BMC Cancer. 2015;15:507. - https://doi.org/10.1186/s12885-015-1527-z
Poligone B, Christensen SR, Lazova R, Heald PW. Bazex syndrome (acrokeratosis paraneoplastica). Lancet. 2007;369(9560):530. - https://doi.org/10.1016/S0140-6736(07)60240-2
Silva JA, Mesquita KC, Igreja AC, Lucas IC, Freitas AF, Oliveira SM et al. Paraneoplastic cutaneous manifestations: concepts and updates. An. Bras. Dermatol.2013;88(1):9-22. - https://doi.org/10.1590/S0365-05962013000100001
Squires B, Daveluy SD, Joiner MC, Hurst N, Bishop M, Miller SR. Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma. Case Rep Dermatol Med. 2016;2016:7137691. - https://doi.org/10.1155/2016/7137691
Villares Soriano J, Vázquez Barro C, Martínez Vidal J. Acroqueratosis de Bazex como síndrome paraneoplásico. Acta Otorrinolaringol Esp. 2014;65:138-9. - https://doi.org/10.1016/j.otorri.2012.10.003
Castañeda-Curto, N., Martino-González, M., & Morales-Angulo, C. (2018). Bazex syndrome related to oropharyngeal carcinoma. Case report. Revista ORL, 10(3), 217–220. https://doi.org/10.14201/orl.18080
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