T-cell nasal lymphoma / Natural Killer. Case report
Abstract Introduction and objective: To state the severity shown by this pathology, updating its more appropriate diagnosis and therapeutic methods. Despite its typical bad prognosis, we can show that favorable cases exist. Description: 43-year-old male suffering nasal obstruction and epistaxis, whose endoscopy reveals an erosive, bleeding and voluminous mass. Results: 3-year-survival, up to now. Discussion: Rare entity in western countries, but more frequent in Asia, that has been treated in different ways all along the years. However, except in unusual cases, prognosis is fateful. Serious complications, even as a result of treatment, can come up and lead to death. Conclusions: Unusual and of a poor prognosis entity, without a standardized treatment. However, there are chances of a good response to it, with satisfactory prospects of the survival rate.
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Jiang M, Chen X, Yi Z, Zhang X, Zhang B, Luo F, et al. Prognostic characteristics of gastrointestinal tract NK/T-cell lymphoma: an analysis of 47 patients in China. J Clin Gastroenterol. 2013;47: e74-9. https://doi.org/10.1097/MCG.0b013e31829e444f - PMid:23948755
Proulx GM, Cuadra-Garcia I, Ferry J, Harris NL, Greco WR, Kaya U, et al. Lymphoma of the nasal cavity and paranasal sinuses. Treatment and outcome of early-stage disease. Am J Clin Oncol. 2003;26:6-11. https://doi.org/10.1097/00000421-200302000-00002 - PMid:12576916
Suzuki R. Pathogenesis and Treatment of Extranodal Natural Killer/T-Cell Lymphoma. Semin Hematol. 2014;51:42-51. https://doi.org/10.1053/j.seminhematol.2013.11.007 - PMid:24468315
Vidal RW, Devaney K, Ferlito A, Rinaldo A, Carbone A. Sinonasal malignant lymphomas: a distinct clinicopathological category. Ann Otol Rhinol Laryngol. 1999;108:411-9. https://doi.org/10.1177/000348949910800417 - PMid:10214792
Zheng S, Ouyang Q, Li G, Xu H, Jiang M, Cui D et al. Primary intestinal NK/T cell lymphoma: a clinicopathologic study of 25 Chinese cases. Arch Iran Med 2012;15: 36-42. - PMid:22208442
Zheng Yan, Hui-qiang Huang, Xiao-xiao Wang, Yan Gao, Yu-jing Zhang, Bing Bai. A. TNM Staging System for Nasal NK/T-Cell Lymphoma. Plos One Journal Taiwan 2015;1-17.
Chan JK, Jaffe E, Ralfkiaer E. Extranodal NK/T lymphomas, nasal type.In: Jaffe E, Harris N, Stein H, Vardiman J, Eds. World Health Organization Classification of Tumours Pathology and Genetics. Tumours of hematopoietic Lymphoid tissue. Lyon. France IARC Press 2001. Pp. 204-7.
Hatta C, Ogasawara H, Okita J, Kubota A, Ishida M, Sakagami M. Non-Hodgkin malignant lymphoma of the sinonasal tract treatment outcome for 53 patients according to REAL classification. Auris Nasus Larynx. 2001;28:55-60. https://doi.org/10.1016/S0385-8146(00)00094-8
Jakic-Razumovic J, Aurer I. The World Health Organization classification of lymphomas. Croat Med J. 2002;43:527-34. - PMid:12402390
Jiang M, Chen X, Yi Z, Zhang X, Zhang B, Luo F, et al. Prognostic characteristics of gastrointestinal tract NK/T-cell lymphoma: an analysis of 47 patients in China. J Clin Gastroenterol. 2013;47: e74-9. https://doi.org/10.1097/MCG.0b013e31829e444f - PMid:23948755
Proulx GM, Cuadra-Garcia I, Ferry J, Harris NL, Greco WR, Kaya U, et al. Lymphoma of the nasal cavity and paranasal sinuses. Treatment and outcome of early-stage disease. Am J Clin Oncol. 2003;26:6-11. https://doi.org/10.1097/00000421-200302000-00002 - PMid:12576916
Suzuki R. Pathogenesis and Treatment of Extranodal Natural Killer/T-Cell Lymphoma. Semin Hematol. 2014;51:42-51. https://doi.org/10.1053/j.seminhematol.2013.11.007 - PMid:24468315
Vidal RW, Devaney K, Ferlito A, Rinaldo A, Carbone A. Sinonasal malignant lymphomas: a distinct clinicopathological category. Ann Otol Rhinol Laryngol. 1999;108:411-9. https://doi.org/10.1177/000348949910800417 - PMid:10214792
Zheng S, Ouyang Q, Li G, Xu H, Jiang M, Cui D et al. Primary intestinal NK/T cell lymphoma: a clinicopathologic study of 25 Chinese cases. Arch Iran Med 2012;15: 36-42. - PMid:22208442
Zheng Yan, Hui-qiang Huang, Xiao-xiao Wang, Yan Gao, Yu-jing Zhang, Bing Bai. A. TNM Staging System for Nasal NK/T-Cell Lymphoma. Plos One Journal Taiwan 2015;1-17.
Rodríguez-Pérez, M. A., Sanmartín-Caballero, A., & Salom-Coveñas, M. C. (2017). T-cell nasal lymphoma / Natural Killer. Case report. Revista ORL, 8(4), 259–262. https://doi.org/10.14201/orl.16861
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