Idiopathic hypoglossal nerve palsy. Case report
Abstract Introduction: Hypoglossal nerve palsy is a rare mononeuropathy. The most common etiologies are tumor, traumatic, cerebral ischemic and iatrogenic causes. Description: We present a man with idiopathic hypoglossal nerve neuropathy. The patient's age, the presence of vascular risk factors and cerebral microangiopathy, and the clinical evolution leads us to discussion about the possibility of a ischemic or diabetic mononeuropathy as the etiology of the deficit. Discussion: In previous published series of idiopathic hypoglossal nerve palsy, the age of presentation is between 20 and 45 years and the patients have a favorable evolution. The pathophysiological mechanism could be similar to Bell's palsy. In our patient the physical examination and the complementary studies were normal, diagnose the deficit as idiopathic hypoglossal nerve palsy. However, due to patient's age, the presence of multiple vascular risk factors, cerebral microangiopathy and the persistence of the symptoms, we consider the existence of a local ischemic or diabetic damage as the cause of the mononeuropathy presented, and we think that the physiopathological mechanism could be similar to other mononeuropathies, such as III or VI cranial nerve palsy. Conclusion: We present an idiopathic hypoglossal nerve palsy, but due to characteristics of our patient, we discuss an ischemic or diabetic cause of the deficit.
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2. Stino AM, Smith BE, Temkit M, Reddy SN. Hypoglossal nerve palsy: 245 cases. Muscle Nerve. 2016;54:1050-1054.
3. Parano E, Giuffrida S, Restivo D, Saponara R, Greco F, Trifiletti RR. Reversible palsy of the hypoglossal nerve complicating infectious mononucleosis in a young child. Neuropediatrics. 1998;29:46-47.
4. Johns MM, Hogikyan ND. Simultaneous vocal fold and tongue paresis secondary to Epstein-Barr virus infection. Arch Otolaryngol Head Neck Surg. 2000;126:1491-1494.
5. Lindsay FW, Mullin D, Keefe MA. Subacute hypoglossal nerve paresis with internal carotid artery dissection. Laryngoscope. 2003;113:1530-1533.
6. Finley JC Jr, Bloom DC, Thiringer JK. Wegener granulomatosis presenting as an infiltrative retropharyngeal mass with syncope and hypoglossal paresis. Arch Otolaryngol Head Neck Surg. 2004;130:361-365.
7. Ko KF, Kwan MC, Chan TP, Kay CS, Lam EK. Isolated hypoglossal nerve palsy in Behçet's disease. Ann Acad Med Singapore. 1997;26:848-849.
8. Goldstein ED, Eidelman BH. Misdiagnosis: Hypoglossal palsy mimicking bulbar onset amyotrophic lateral sclerosis. eNeurologicalSci. 2018;14:6-8.
9. Robaina Bordón JM, González Hernández A, Curutchet Mesner L, Gil Díaz A. Isolated hypoglossal nerve palsy. Neurologia. 2019;34:125-127.
10. Ahmed SV, Akram MS. Isolated unilateral idiopathic transient hypoglossal nerve palsy. BMJ Case Rep. 2014; 26;2014.
11. Shikino K, Noda K, Ikusaka M. Transient idiopathic isolated unilateral hypoglossal nerve palsy. J Gen Intern Med. 2013;28:591.
12. Nestola DF, Lombardi M, Brucoli M, Pia F, Aluffi P. Isolated Hypoglossal Nerve Palsy Mimicking a Base of Tongue Tumor. J Craniofac Surg. 2017;28:e78-e80.
13. Semiz S, Fi?enk F, Akçurin S, Bircan I. Temporary multiple cranial nerve palsies in a patient with type 1 diabetes mellitus. Diabetes Metab. 2002;28:413-416.
Gallego-Sánchez, Y., Vicente-Pascual, M., Vázquez-Justes, D., & Andreu-Mencia, L. (2020). Idiopathic hypoglossal nerve palsy. Case report. Revista ORL, 12(1), 85–88. https://doi.org/10.14201/orl.23513
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