Drug delivery from liposomes in different biorelevant media
Abstract Liposomes provide ideal vesicular systems for controlled release and vectorization of drugs through pulmonary administration, due to their similarity to cell membranes and their great versatility. Sildenafil citrate, represents an optimal model of drug to be incorporated into these lipid vesicles for the treatment of pulmonary hypertension. The objective of the work was to characterize the behavior of liposomes loaded with sildenafil and evaluate the transfer of the drug in different bio-resistant media. Liposomes of two sizes (0.45 and 0.20 microns) were developed by sonication. Subsequently, the drug release test was carried out in different biorelevant media (simulated plasma fluid SBF, simulated pulmonary fluid SPF and PBS). According to the results obtained, a more sustained and consistent rate of release of the drug was observed over time in the case of liposomes, regardless of the medium. In PBS and SPF media, a greater amount of drug was released from the larger liposomes (0.45 microns), however, in the SBF the transfer kinetics of both liposome sizes (0.45µm and 0.20 µm) are very similar, with no significant differences in the time or amount of drug released
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Daraee H, Etemadi A, Kouhi M, Alimirzalu S, Akbarzadeh A. Application of liposomes in medicine and drug delivery. Artificial Cells, Nanomedicine and Biotechnology. 2016; 4(4):381-391.
De Jesús MJ, Gil P, Prata M, Araujo A RTS, Sánchez A. Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization. Applied sciences. 2018; (8).
De Jesús Valle MJ, Sánchez Navarro A. Liposomes prepared in absence of organic solvents: sonication versus lipid film hydration method. Current pharmaceutical análisis. 2015; (11):86-91.
E. Villanueva DL, Divine Agustin R, Jasper Llanes E. Pre-operative sildenafil for patients with pulmonary hypertension undergoing mitral valve surgery: a systematic review and meta-analysis. Elmer press. 2019; (10):369-377.
Javeri I, Nellaiappan K. Methods for the preparation of liposomes. US. 10, 143, 652 B2. 2018.
Kumar A, Terakosolphan W, Hassoun M, Vandera KK, Novicky A, Harvey R et al. A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition. Pharmaceutical Research. 2017; (34):2454-2465.
Lavie-Nevo K, C. Harris K, Y. Ting J. Use of sildenafil in an infant with persistent pulmonary hypertension secondary to lung and renal hipoplasia- a case report. BMC pedriatics. 2019; (19):416.
Marques MRC, Loebenberg, R. Almukainzi, M. Simulated biological fluids with possible application in dissolution testing. Dissolution technologies. 2011; (18):15-28.
Ming Ong SG, Chitneni M, Seng Lee K, Chiau Ming L, Hay Yuen K. Evaluation of Extrusion Technique for Nanosizing Liposomes. Pharmaceutics. 2016; (8).
Paranjpe M, Müller-Goymann CC. Nanoparticle-Mediated Pulmonary Drug Delivery: A Review. International Journal of Molecular Sciences. 2014; (15):5852-5873.
Sánchez MJ, Sánchez A, De Jesús MJ. Caracterización y separación de liposomas por microencapsulación. FarmaJournal. 2016; (1):93-100.
Shahin HI, Vinjamuri BP, Mahmoud AA, Shamma RN, Mansour SM, Ammar HO et al. Design and Evaluation of Novel Inhalable Sildenafil Citrate Spray-Dried Microparticles for Pulmonary Arterial Hypertension. Journal of Controlled Release. 2019; (302):126-139.
Simonca L, Tulloh T. Sildenafil in Infants and Children. Children. 2017; (4).
Van der Graaf M, Arindah Rojer L, Arnold Helbing W, Marcel Reiss IK, Gregory Etnel JR, Bartelds B. Sildenafil for bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis. Pulmonary circulation. 2019; (9):1-8.
Toro, A. I., & de Jesús Valle, M. J. (2021). Drug delivery from liposomes in different biorelevant media. FarmaJournal, 6(1), 75–84. https://doi.org/10.14201/fj2021617584
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