Silver nanoparticles as antibacterial agents in bone tissue infections
Abstract
Bone tissue engineering is an area of increasing interest because its main applications are directly related to the rising life expectancy of the population, so innovative strategies are needed for bone tissue regeneration therapies. Advances in biomedicine and materials science are determining factors in this field, since they pursue to design new biomaterials to subsequently implant them in order to replace, repair and regenerate damaged bone tissue.
Post-operative implant infections are one of the most serious complications associated with surgical treatments of bone diseases. Bacteria typically secrete polymeric materials after their association to form protective coatings known as biofilms. Biofilm further impedes the activity of the host defenses and/or antibiotic therapy, requiring surgical intervention to remove the implant as the only effective option. Silver is an antibacterial agent that could be used as a preventive measure to avoid the formation of a bacterial biofilm in implants by incorporation of metallic silver nanoparticles.
The present work is focused in finding a preventive treatment of bone infection with metallic silver nanoparticles embedded. It describes their behavior as antibacterial agents and possible toxicity.
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Imágenes adaptadas de las siguientes referencias:
Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010;28(11):580–8.
Kubba A, Kubba R, Batrani M, Pal T. Argyria an unrecognized cause of cutaneous pigmentation in Indian patients: A case series and review of the literature. Indian J Dermatology, Venereol Leprol. 2013;79(6):805.
Loza K, Diendorf J, Sengstock C, Ruiz-Gonzalez L, Gonzalez-Calbet JM, Vallet-Regi M. The dissolution and biological effects of silver nanoparticles in biological media. J Mater Chem B. 2014;2(12):1634.
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