Silver nanoparticles as antibacterial agents in bone tissue infections
Abstract Bone tissue engineering is an area of increasing interest because its main applications are directly related to the rising life expectancy of the population, so innovative strategies are needed for bone tissue regeneration therapies. Advances in biomedicine and materials science are determining factors in this field, since they pursue to design new biomaterials to subsequently implant them in order to replace, repair and regenerate damaged bone tissue.Post-operative implant infections are one of the most serious complications associated with surgical treatments of bone diseases. Bacteria typically secrete polymeric materials after their association to form protective coatings known as biofilms. Biofilm further impedes the activity of the host defenses and/or antibiotic therapy, requiring surgical intervention to remove the implant as the only effective option. Silver is an antibacterial agent that could be used as a preventive measure to avoid the formation of a bacterial biofilm in implants by incorporation of metallic silver nanoparticles.The present work is focused in finding a preventive treatment of bone infection with metallic silver nanoparticles embedded. It describes their behavior as antibacterial agents and possible toxicity.
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Alexander JW. History of the Medical Use of Silver. Surg Infect (Larchmt). 2009;10(3):289–92.
Bart?omiejczyk T, Lankoff A, Kruszewski M, Szumiel I. Silver nanoparticles - Allies or adversaries? Ann Agric Environ Med. 2013;20(1):48-54.
Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010;28(11):580–8.
Chatterjee T, Chatterjee BK, Majumdar D, Chakrabarti P. Antibacterial effect of silver nanoparticles and the modeling of bacterial growth kinetics using a modified Gompertz model. Biochim Biophys Acta - Gen Subj. 2015;1850(2):299–306.
Chernousova S, Epple M. Silver as antibacterial agent: Ion, nanoparticle, and metal. Angew Chemie - Int Ed. 2013;52(6):1636–53.
Ducheyne P. Comprehensive Biomaterials. 1.a ed. II. Elsevier; 2017. p. 81-87.
Gupta P, Sarkar S, Das B, Bhattacharjee S, Tribedi P. Biofilm, pathogenesis and prevention—a journey to break the wall: a review. Arch Microbiol. 2016;198(1):1–15.
Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, et al. Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect Control Hosp Epidemiol. 2008;29(11):996–1011.
Kubba A, Kubba R, Batrani M, Pal T. Argyria an unrecognized cause of cutaneous pigmentation in Indian patients: A case series and review of the literature. Indian J Dermatology, Venereol Leprol. 2013;79(6):805.
Lansdown ABG. Silver in health care: Antimicrobial effects and safety in use. Curr Probl Dermatol. 2006;33:17–34.
Loza K, Diendorf J, Sengstock C, Ruiz-Gonzalez L, Gonzalez-Calbet JM, Vallet-Regi M. The dissolution and biological effects of silver nanoparticles in biological media. J Mater Chem B. 2014;2(12):1634.
Monge M. Nanopartículas de plata?: métodos de síntesis en disolución y propiedades bactericidas. Investig Quim. 2009;(August):33–41.
Qing T, Mahmood M, Zheng Y, Biris AS, Shi L, Casciano DA. A genomic characterization of the influence of silver nanoparticles on bone differentiation in MC3T3-E1 cells. J Appl Toxicol. 2018;38(2):172–9.
Salinas AJ, Vallet-Regí M. Evolution of ceramics with medical applications. Zeitschrift fur Anorg und Allg Chemie. 2007;633(11–12):1762–73.
Xiu Z, Zhang Q, Puppala HL, Colvin VL, Álvarez PJJ. Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles. Nano Lett. 2012;12(8):4271–5.9.
Imágenes adaptadas de las siguientes referencias:
Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010;28(11):580–8.
Kubba A, Kubba R, Batrani M, Pal T. Argyria an unrecognized cause of cutaneous pigmentation in Indian patients: A case series and review of the literature. Indian J Dermatology, Venereol Leprol. 2013;79(6):805.
Loza K, Diendorf J, Sengstock C, Ruiz-Gonzalez L, Gonzalez-Calbet JM, Vallet-Regi M. The dissolution and biological effects of silver nanoparticles in biological media. J Mater Chem B. 2014;2(12):1634.
Bart?omiejczyk T, Lankoff A, Kruszewski M, Szumiel I. Silver nanoparticles - Allies or adversaries? Ann Agric Environ Med. 2013;20(1):48-54.
Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010;28(11):580–8.
Chatterjee T, Chatterjee BK, Majumdar D, Chakrabarti P. Antibacterial effect of silver nanoparticles and the modeling of bacterial growth kinetics using a modified Gompertz model. Biochim Biophys Acta - Gen Subj. 2015;1850(2):299–306.
Chernousova S, Epple M. Silver as antibacterial agent: Ion, nanoparticle, and metal. Angew Chemie - Int Ed. 2013;52(6):1636–53.
Ducheyne P. Comprehensive Biomaterials. 1.a ed. II. Elsevier; 2017. p. 81-87.
Gupta P, Sarkar S, Das B, Bhattacharjee S, Tribedi P. Biofilm, pathogenesis and prevention—a journey to break the wall: a review. Arch Microbiol. 2016;198(1):1–15.
Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, et al. Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect Control Hosp Epidemiol. 2008;29(11):996–1011.
Kubba A, Kubba R, Batrani M, Pal T. Argyria an unrecognized cause of cutaneous pigmentation in Indian patients: A case series and review of the literature. Indian J Dermatology, Venereol Leprol. 2013;79(6):805.
Lansdown ABG. Silver in health care: Antimicrobial effects and safety in use. Curr Probl Dermatol. 2006;33:17–34.
Loza K, Diendorf J, Sengstock C, Ruiz-Gonzalez L, Gonzalez-Calbet JM, Vallet-Regi M. The dissolution and biological effects of silver nanoparticles in biological media. J Mater Chem B. 2014;2(12):1634.
Monge M. Nanopartículas de plata?: métodos de síntesis en disolución y propiedades bactericidas. Investig Quim. 2009;(August):33–41.
Qing T, Mahmood M, Zheng Y, Biris AS, Shi L, Casciano DA. A genomic characterization of the influence of silver nanoparticles on bone differentiation in MC3T3-E1 cells. J Appl Toxicol. 2018;38(2):172–9.
Salinas AJ, Vallet-Regí M. Evolution of ceramics with medical applications. Zeitschrift fur Anorg und Allg Chemie. 2007;633(11–12):1762–73.
Xiu Z, Zhang Q, Puppala HL, Colvin VL, Álvarez PJJ. Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles. Nano Lett. 2012;12(8):4271–5.9.
Imágenes adaptadas de las siguientes referencias:
Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010;28(11):580–8.
Kubba A, Kubba R, Batrani M, Pal T. Argyria an unrecognized cause of cutaneous pigmentation in Indian patients: A case series and review of the literature. Indian J Dermatology, Venereol Leprol. 2013;79(6):805.
Loza K, Diendorf J, Sengstock C, Ruiz-Gonzalez L, Gonzalez-Calbet JM, Vallet-Regi M. The dissolution and biological effects of silver nanoparticles in biological media. J Mater Chem B. 2014;2(12):1634.
González-Jiménez, A., & García, A. (2020). Silver nanoparticles as antibacterial agents in bone tissue infections. FarmaJournal, 5(1), 27–36. https://doi.org/10.14201/fj2020512736
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