Design and Development of a Diaper Cream with Donkey Milk
Abstract Due to the prevalence of diaper dermatitis in infancy, a condition that causes skin irritation and inflammation in the area of the baby that is in direct contact with the diaper, it was decided to find a solution to this problem. For this, after studying the pathology in depth, a diaper cream capable of preventing, palliating and/or treating the problem was developed. Among its ingredients, it has donkey milk, a component that has been shown to have the ability to improve the problem described.
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Aspri M, Economou N, Papademas P. Donkey milk: An overview on functionality, technology, and future prospects. Food Reviews International. 2017; 33(3):316-333. https://doi.org/10.1080/87559129.2016.1175014
Blume-Peytavi U, Hauser M, Lünnemann L, Stamatas GN, Kottner J, Garcia Bartels N. Prevention of Diaper Dermatitis in Infants-a Literature Review. Pediatric Dermatology. 2014; 31(4):413-429. https://doi.org/10.1111/pde.12348
Honfo FG, Akissoe N, Linnemann AR, Soumanou M, Van Boekel MAJS. Nutritional Composition of Shea Products and Chemical Properties of Shea Butter: A Review. Critical Reviews in Food Science and Nutrition. 2014; 54(5):673-686. https://doi.org/10.1080/10408398.2011.604142
Klunk C, Domingues E, Wiss K. An update on diaper dermatitis. Clinics in Dermatology. 2014; 32(4):477-487. https://doi.org/10.1016/j.clindermatol.2014.02.003
Kocic H, Stankovic M, Tirant M, Lotti T, Arsic I. Favorable effect of creams with skimmed donkey milk encapsulated in nanoliposomes of skin physiology. Dermatologic Therapy. 2020; 33(4):23. https://doi.org/10.1111/dth.13511
Kovács A, Péter-Héderi D, Perei K, Budai-Szűcs M, Léber A, Gácsi A, Csányi E, Berkó S. Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care. Pharmaceutics. 2020; 12(8):1-15. https://doi.org/10.3390/pharmaceutics12080729
Li Y, Ma Q, Liu G, Wang C. Effects of donkey milk on oxidative stress and inflammatory response. Journal of Food Biochemistry. 2022; 46(4):1-15. https://doi.org/10.1111/jfbc.13935
Martini M, Altomonte I, Tricò D, Lapenta R, Salari F. Current Knowledge on Functionality and Potential Therapeutic Uses of Donkey Milk. Animals. 2021; 11(5):1-15. https://doi.org/10.3390/ani11051382
Ouzir M, Bernoussi SE, Tabyaoui M, Taghzouti K. Almond oil: A comprehensive review of chemical composition, extraction methods, preservation conditions, potential health benefits, and safety. Comprehensive Reviews in Food Science and Food Safety. 2021; 20(4):3344-3387. https://doi.org/10.1111/1541-4337.12752
Šikić Pogačar M, Maver U, Marčun Varda N, Mičetić-Turk, D. Diagnosis and management of diaper dermatitis in infants with emphasis on skin microbiota in the diaper area. International Journal of Dermatology. 2018; 57(3):265-275. https://doi.org/10.1111/ijd.13748
Thakur NK. Formulation and Characterization of Benzoyl Peroxide Gellified Emulsions. Scientia Pharmaceutica. 2012; 80(4):1045-1060. https://doi.org/10.3797/scipharm.1206-09
Vita D, Passalacqua G, Di Pasquale G, Caminiti L, Crisafulli G, Rulli I, Pajno GB. Ass’s milk in children with atopic dermatitis and cow’s milk allergy: Crossover comparison with goat’s milk. Pediatric Allergy and Immunology. 2007; 18(7):594-598. https://doi.org/10.1111/j.1399-3038.2007.00567.x
Zakaria R, Musa RJ, Faraj J, Mahmoud Abudayeh ZH, Mohammed HA. Evaluation of the Wheat Germ Oil Topical Formulations for Wound Healing Activity in Rats. Pakistan Journal of Biological Sciences. 2021; 24(6):706-715.
Zimecki M, Artym J. Therapeutic properties of proteins and peptides from colostrum and milk. Postepy higieny i medycyny doswiadczalnej. 2005; 59:309-323.
Aspri M, Economou N, Papademas P. Donkey milk: An overview on functionality, technology, and future prospects. Food Reviews International. 2017; 33(3):316-333. https://doi.org/10.1080/87559129.2016.1175014
Blume-Peytavi U, Hauser M, Lünnemann L, Stamatas GN, Kottner J, Garcia Bartels N. Prevention of Diaper Dermatitis in Infants-a Literature Review. Pediatric Dermatology. 2014; 31(4):413-429. https://doi.org/10.1111/pde.12348
Honfo FG, Akissoe N, Linnemann AR, Soumanou M, Van Boekel MAJS. Nutritional Composition of Shea Products and Chemical Properties of Shea Butter: A Review. Critical Reviews in Food Science and Nutrition. 2014; 54(5):673-686. https://doi.org/10.1080/10408398.2011.604142
Klunk C, Domingues E, Wiss K. An update on diaper dermatitis. Clinics in Dermatology. 2014; 32(4):477-487. https://doi.org/10.1016/j.clindermatol.2014.02.003
Kocic H, Stankovic M, Tirant M, Lotti T, Arsic I. Favorable effect of creams with skimmed donkey milk encapsulated in nanoliposomes of skin physiology. Dermatologic Therapy. 2020; 33(4):23. https://doi.org/10.1111/dth.13511
Kovács A, Péter-Héderi D, Perei K, Budai-Szűcs M, Léber A, Gácsi A, Csányi E, Berkó S. Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care. Pharmaceutics. 2020; 12(8):1-15. https://doi.org/10.3390/pharmaceutics12080729
Li Y, Ma Q, Liu G, Wang C. Effects of donkey milk on oxidative stress and inflammatory response. Journal of Food Biochemistry. 2022; 46(4):1-15. https://doi.org/10.1111/jfbc.13935
Martini M, Altomonte I, Tricò D, Lapenta R, Salari F. Current Knowledge on Functionality and Potential Therapeutic Uses of Donkey Milk. Animals. 2021; 11(5):1-15. https://doi.org/10.3390/ani11051382
Ouzir M, Bernoussi SE, Tabyaoui M, Taghzouti K. Almond oil: A comprehensive review of chemical composition, extraction methods, preservation conditions, potential health benefits, and safety. Comprehensive Reviews in Food Science and Food Safety. 2021; 20(4):3344-3387. https://doi.org/10.1111/1541-4337.12752
Šikić Pogačar M, Maver U, Marčun Varda N, Mičetić-Turk, D. Diagnosis and management of diaper dermatitis in infants with emphasis on skin microbiota in the diaper area. International Journal of Dermatology. 2018; 57(3):265-275. https://doi.org/10.1111/ijd.13748
Thakur NK. Formulation and Characterization of Benzoyl Peroxide Gellified Emulsions. Scientia Pharmaceutica. 2012; 80(4):1045-1060. https://doi.org/10.3797/scipharm.1206-09
Vita D, Passalacqua G, Di Pasquale G, Caminiti L, Crisafulli G, Rulli I, Pajno GB. Ass’s milk in children with atopic dermatitis and cow’s milk allergy: Crossover comparison with goat’s milk. Pediatric Allergy and Immunology. 2007; 18(7):594-598. https://doi.org/10.1111/j.1399-3038.2007.00567.x
Zakaria R, Musa RJ, Faraj J, Mahmoud Abudayeh ZH, Mohammed HA. Evaluation of the Wheat Germ Oil Topical Formulations for Wound Healing Activity in Rats. Pakistan Journal of Biological Sciences. 2021; 24(6):706-715.
Zimecki M, Artym J. Therapeutic properties of proteins and peptides from colostrum and milk. Postepy higieny i medycyny doswiadczalnej. 2005; 59:309-323.
Bautista Sánchez, B., & Zarzuelo Castañeda, A. (2023). Design and Development of a Diaper Cream with Donkey Milk. FarmaJournal, 8(1), 21–31. https://doi.org/10.14201/fj2023812131
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