ncRNA Study in Males with Breast Cancer
Abstract Male breast cancer (BC) is a rare disease accounting for less than 1% of all BC detected. For this reason, it would be important to find ways to prevent this kind of cancer, to know how it develops in men and if there is any genetic predisposition to have BC. We know that noncoding RNA (ncRNA) are involved in female breast cancer but there is no information about their role in males. In this paper we try to find if some ncRNA have implications in male BC. Specifically, we have studied some single nucleotide polymorphisms of the genes encoding for mir-146A, mir-196A2, mir-499A and long noncoding RNA, HotAIR. The technique used was genotyping with taqman probe, that allows to discriminate between different polymorphisms. The genetic counsil of cancer research center provides us with the study population. The preliminary results showed that the allele C of the polymorphism with rs2910164 of the mir-146A gene and the genotype CA of the polymorphism with rs1899663 of the HotAIR gene could protect males from developing BC.
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Bayram S., Sümbul A.T. y Dada? E., A funtional HOTAIR rs12826786 C>T polymorphism is associated with breast cancer susceptibility and poor clinicopathological characteristics in a Turkish population: a hospital-based case-control study. Tumor Biol. (2016); 37(4):5577-84. DOI: 10.1007/s13277-015-4430-y
Catucci I., Yang R., Verderio P., Pizzamiglio S., Heesen L., Hemminki K., Sutter C., Wappenschmidt B., Dick M., Arnold N., Bugert P., Niederacher D., Meindl A., Schmutzler R.K., Bartram C.C., Ficarazzi F., Tizzoni L., Zaffaroni D., Manoukian S., Barile M., Pierotti M.A., Radice P., Burwinkel B., Peterlongo P., Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. Hum Mutat. (2010); 31(1):E1052-7. DOI: 10.1002/humu.21141
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Dai Z.M., Kang H.F., Zhang W.G., Li H.B., Zhang S.Q., Ma X.B., Lin S., Wang M., Feng Y.J., Liu K., Liu X.H., Xu P., Dai Z.J., The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. Medicine (Baltimore). (2016); 95(7):e2826. DOI: 10.1097/MD.0000000000002826
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Peng Y, Croce CM. The role of MicroRNAs in human cancer. Signal Transduct Target Ther. (2016); 28;1:15004. DOI: 10.1038/sigtrans.2015.4.
Tang Q., Hann S. S., HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer, Cell Physiol Biochem (2018); 47:893-913 DOI: 10.1159/000490131
Upadhyaya K., Smith R.A., Chacon-Cotes D., Revêchon G., Bellis C., Lea R.A., Haupt L.M., Chambers S.K., Youl P. H., Griffiths L.R., Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study, Gene (2016); 576, 256-260. DOI: 10.1016/j.gne.2015.10.019
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What is epigenetics?, non-coding RNA [Internet], What is epigenetics?, [Consultado 26 de enero 2019] Disponible en: https://www.whatisepigenetics.com/non-coding-rna/
Zhang L.H., Hao B.B., Zhang C.Y., Dai X.Z. and Zhang F., Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma, Genet. Mol. Res. (2016); 15: 3, DOI: 10.4238/gmr.15038582
Bayram S., Sümbul A.T. y Dada? E., A funtional HOTAIR rs12826786 C>T polymorphism is associated with breast cancer susceptibility and poor clinicopathological characteristics in a Turkish population: a hospital-based case-control study. Tumor Biol. (2016); 37(4):5577-84. DOI: 10.1007/s13277-015-4430-y
Catucci I., Yang R., Verderio P., Pizzamiglio S., Heesen L., Hemminki K., Sutter C., Wappenschmidt B., Dick M., Arnold N., Bugert P., Niederacher D., Meindl A., Schmutzler R.K., Bartram C.C., Ficarazzi F., Tizzoni L., Zaffaroni D., Manoukian S., Barile M., Pierotti M.A., Radice P., Burwinkel B., Peterlongo P., Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. Hum Mutat. (2010); 31(1):E1052-7. DOI: 10.1002/humu.21141
Collins L.J., Schönfeld B., Chen X.S., Handobook of epigenetics (2011); Pág: 49-61, Chapter4 – the epidenetics of non-codingRNA, DOI: 10.1016/B978-0-12-375709-8.00004-6
Dai Z.M., Kang H.F., Zhang W.G., Li H.B., Zhang S.Q., Ma X.B., Lin S., Wang M., Feng Y.J., Liu K., Liu X.H., Xu P., Dai Z.J., The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. Medicine (Baltimore). (2016); 95(7):e2826. DOI: 10.1097/MD.0000000000002826
Hu Z., Liang J., Wang Z., Tian T., Zhou X., Chen J., Miao R., Wang Y., Wang X., Shen H., Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum Mutat. (2009); 30(1):79-84. DOI: 10.1002/humu.20837
Jeffares, D., Poole, A. y Penny, D. J Mol Evol (1998); 46: 18. DOI: 10.1007/PL00006280
Li J., Liu R., Tang S., Feng F., Wang X., Qi L., Liu C., Yao Y., Sun C., The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single-nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta-analysis. J Cell Biochem. (2018); 28. DOI: 10.1002/jcb.27975.
PATIA ¿En qué consiste el genotipado? [Internet], Patia diabetes, (8 marzo 2016) [consultado 22 enero 2019] Disponible en: http://www.patiadiabetes.com/faq-items/consiste-genotipado/
Peng Y, Croce CM. The role of MicroRNAs in human cancer. Signal Transduct Target Ther. (2016); 28;1:15004. DOI: 10.1038/sigtrans.2015.4.
Tang Q., Hann S. S., HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer, Cell Physiol Biochem (2018); 47:893-913 DOI: 10.1159/000490131
Upadhyaya K., Smith R.A., Chacon-Cotes D., Revêchon G., Bellis C., Lea R.A., Haupt L.M., Chambers S.K., Youl P. H., Griffiths L.R., Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study, Gene (2016); 576, 256-260. DOI: 10.1016/j.gne.2015.10.019
Vieira, F.M.J., Porfiria cutânea tardia com mutações do gene da hemocromatose C282Y e H63D e análise retrospectiva do perfil de ferro em relação ao tratamento: estudo de 60 casos [tesis]. São Paulo: Faculdade de Medicina; (2012) [acceso 2020-1-23]. Disponible en: http://www.teses.usp.br/teses/disponiveis/5/5133/tde-24012013-170707/.
What is epigenetics?, non-coding RNA [Internet], What is epigenetics?, [Consultado 26 de enero 2019] Disponible en: https://www.whatisepigenetics.com/non-coding-rna/
Zhang L.H., Hao B.B., Zhang C.Y., Dai X.Z. and Zhang F., Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma, Genet. Mol. Res. (2016); 15: 3, DOI: 10.4238/gmr.15038582
Díez Castro, D., Ovejero Sánchez, M., & González Sarmiento, R. (2021). ncRNA Study in Males with Breast Cancer. FarmaJournal, 6(1), 27–37. https://doi.org/10.14201/fj2021612737
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