Non-coding RNA polymorphisms research in Hereditary breast and ovarian cancer syndrome
Abstract
The relation between the non-coding RNA polymorphisms and the possible predisposition to suffer different kinds of cancer has been studied for quite some time. This research studies the correlation between single nucleotide polymorphisms (SNPs) in 5 genes (miR-146A, miR-196A2, miR-499A and two HOTAIR SNPs) and the predisposition to develop breast and ovary cancer. The size of the studied sample was 99 patients and 133 controls. The method used for the analysis of the samples genotype was the Taqman allelic discrimination assay and afterwards, a statistical analysis was done, which indicated that any of the studied genotypes showed significant statistical difference between the patients and the controls. With the results obtained (p > 0,05 in every case) we could conclude that the presence of SNPs in the studied genes is unrelated with the predisposition to develop breast and ovary cancer in the studied population.
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Bayram S, Sümbül AT, Dada? E. A functional HOTAIR rs12826786 C>T polymorphism is associated with breast cancer susceptibility and poor clinicopathological characteristics in a Turkish population: a hospital-based case-control study. Tumour Biol. 2016; 37(4):5577-84. https://doi.org/10.1007/s13277-015-4430-y
Catucci I, Yang R, Verderio P, Pizzamiglio S, Heesen L, Hemminki K et al. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. Hum Mutat. 2010; 31(1): e1052-7. https://doi.org/10.1002/humu.21141
Dai ZM, Kang HF, Zhang WG, Li HB, Zhang SQ, Ma XB et al. The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. Medicine (Baltimore). 2016; 95(7): e2826. https://doi.org/10.1097/MD.0000000000002826
Hereditary Breast and Ovarian Cancer Syndrome - NORD (National Organization for Rare Disorders) [Internet]. NORD (National Organization for Rare Disorders). 2018 [citado 24 jun 2019]. Disponible en: https://rarediseases.org/rare-diseases/hereditary-breast-ovarian-cancer-syndrome/
Jie Shen, Christine B. Ambrosone, Richard A. DiCioccio, Kunle Odunsi, Shashikant B. Lele, Hua Zhao, A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis. 2008; 29(10): 1963-1966 https://doi.org/10.1093/carcin/bgn172
Khorshidi H R, Taheri M, Noroozi R, Soudyab M, Sayad A, et al. Investigation of the Association of HOTAIR Single Nucleotide Polymorphisms and Risk of Breast Cancer in an Iranian Population. Int J Cancer Manag. 2017; 10(5):e7498. https://doi.org/10.5812/ijcm.7498
Lux MP, Fasching PA, Beckmann MW. Hereditary breast and ovarian cancer: review and future perspectives. J Mol Med (Berl). 2006; 84(1):16-28. https://doi.org/10.1007/s00109-005-0696-7
Non-Coding RNA | What is Epigenetics? [Internet]. What is Epigenetics? 2019 [citado 26 may 2019]. Disponible en: https://www.whatisepigenetics.com/non-coding-rna/
Peng Y., Croce CM. The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 2016; 1:15004. https://doi.org/10.1038/sigtrans.2015.4
Tang Q, Hann SS. HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer. Cell Physiol Biochem. 2018; 47(3):893-913. https://doi.org/10.1159/000490131
Catucci I, Yang R, Verderio P, Pizzamiglio S, Heesen L, Hemminki K et al. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. Hum Mutat. 2010; 31(1): e1052-7. https://doi.org/10.1002/humu.21141
Dai ZM, Kang HF, Zhang WG, Li HB, Zhang SQ, Ma XB et al. The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. Medicine (Baltimore). 2016; 95(7): e2826. https://doi.org/10.1097/MD.0000000000002826
Hereditary Breast and Ovarian Cancer Syndrome - NORD (National Organization for Rare Disorders) [Internet]. NORD (National Organization for Rare Disorders). 2018 [citado 24 jun 2019]. Disponible en: https://rarediseases.org/rare-diseases/hereditary-breast-ovarian-cancer-syndrome/
Jie Shen, Christine B. Ambrosone, Richard A. DiCioccio, Kunle Odunsi, Shashikant B. Lele, Hua Zhao, A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis. 2008; 29(10): 1963-1966 https://doi.org/10.1093/carcin/bgn172
Khorshidi H R, Taheri M, Noroozi R, Soudyab M, Sayad A, et al. Investigation of the Association of HOTAIR Single Nucleotide Polymorphisms and Risk of Breast Cancer in an Iranian Population. Int J Cancer Manag. 2017; 10(5):e7498. https://doi.org/10.5812/ijcm.7498
Lux MP, Fasching PA, Beckmann MW. Hereditary breast and ovarian cancer: review and future perspectives. J Mol Med (Berl). 2006; 84(1):16-28. https://doi.org/10.1007/s00109-005-0696-7
Non-Coding RNA | What is Epigenetics? [Internet]. What is Epigenetics? 2019 [citado 26 may 2019]. Disponible en: https://www.whatisepigenetics.com/non-coding-rna/
Peng Y., Croce CM. The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 2016; 1:15004. https://doi.org/10.1038/sigtrans.2015.4
Tang Q, Hann SS. HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer. Cell Physiol Biochem. 2018; 47(3):893-913. https://doi.org/10.1159/000490131
Rosón, M., & González, R. (2020). Non-coding RNA polymorphisms research in Hereditary breast and ovarian cancer syndrome. FarmaJournal, 5(2), 83–91. https://doi.org/10.14201/fj2020528391
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