Microencapsulation of ciprofloxacin in microspheres of albumin and liposomes (Albusomes)
Abstract : Fluoroquinolones are bactericidal agents showing a broad antimicrobial spectrum used for several infectious diseases. Liposomes are excellent carriers for controlled drug delivery and albumin shows a great capacity for binding and transport of solutes. The aim of this study was to incorporate ciprofloxacin into a formulation based on the combination of liposomes and albumin in order to gather the advantages of both components into a single pharmaceutical vehicle.Liposomes were prepared by sonication, in absence of organic solvents, by using ciprofloxacin solutions of different concentration. The albusomes were prepared by mixing these with bovine serum albumin. The influence of three variables on the drug encapsulation efficiency was evaluated: liposomes composition, ciprofloxacin concentration and albumin amount; an HPLC technique was used for drug quantification.The results of the study reveal that liposomes composition significantly affects the entrapment efficiency registered while ciprofloxacin concentration does not affect this parameter
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Norville IH, Hatch GJ, Bewley KR, Atkinson DJ, Hamblin KA, Blanchard JD et al. Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever. Antimicrob. Agents Chemother. 2014; 58(9): 5510-5518
Serisier DJ, Bilton D, De Soyza A, Thompson PJ, Kolbe J, Greville HW et al. Inhaled, dual release liposomal ciprofloxacin in non-cytic fibrosis bronchiectasis (ORBIT-2): a randomized, double blind, placebo-controlled trial. Thorax. 2013; 68(9): 812-817
Taha EI, El-Anazi MH, El-Bagory IM, Bayomi MA. Design of liposomal coloidal systems for ocular delivery of ciprofloxacin. Saudi Pharm. J. 2014; 22(3): 231-239
Bairagi U, Mittal P, Mishra B. Albumin: a versatile drug carrier. Austin Therapeutics. 2015; 2(2): 1021
Bakker-Woudenberg IA, ten Kate MT, Guo L, Working P, Mouton JW. Improved efficacy of ciprofloxacin administered in polyethylene glycol-coated liposomes for treatment of Klebsiella pneumoniae pneumonia in rats. Antimicrob. Agents Chemother. 2001; 45(5): 1487-1492
Bakker-Woudenberg IA, ten Kate MT, Guo L, Working P, Mouton JW. Ciprofloxacin in polyethylene glycol-coated liposomes: efficacy in rat models of acute or chronic Pseudomonas aeruginosa infection. Antimicrob. Agents Chemother. 2002; 46(8): 2575-2581
Budai L, Hajdú M, Budai M, Gróf P, Béni S, Noszál B et al. Gels and liposomes in optimized ocular drug delivery: studies on ciprofloxacin formulations. Int. J. Pharm. 2007; 343(1-2): 34-40
Cipolla D, Wu H, Gonda I, Chan HK. Aerosol performance and long-term stability of surfactant-associated liposomal ciprofloxacin formulations with modified encapsulation and release properties. AAPS PharmSciTech. 2014; 15(5): 1218-1227
Cipolla D, Wu H, Gonda I, Eastman S, Redelmeier T, Chan HK. Modifying the release properties of liposomes toward personalized medicine. J. Pharm. Sci. 2014; 103(6): 1851-1862
Hamblin KA, Wong JP, Blanchard JD, Atkins HS. The potential of liposome-encapsulated ciprofloxacin as a tularemia therapy. Front Cell Infect Microbiol. 2014; 4:79
Hosny KM. Ciprofloxacin as ocular liposomal hydrogel. AAPS PharmSciTech. 2010; 11(1): 241-246
Jesús Valle MJ, Sánchez Navarro A. Liposomes prepared in absence of organic solvents: sonication versus lipid film hydration method. Curr Pharm Anal. 2015; 11(2): 86-91
Kratz F. Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J. Control. Release. 2008; 132(3): 171-183
Mehravar R, Jahanshahi M, Saghatoleslami N. Human serum albumin (HSA) nanoparticles as drug delivery system: preparation, optimization and characterization study. Dyn Biochem Process Biotechnol Mol Biol. 2009; 3(Special Issue 2): 51-56
Norville IH, Hatch GJ, Bewley KR, Atkinson DJ, Hamblin KA, Blanchard JD et al. Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever. Antimicrob. Agents Chemother. 2014; 58(9): 5510-5518
Serisier DJ, Bilton D, De Soyza A, Thompson PJ, Kolbe J, Greville HW et al. Inhaled, dual release liposomal ciprofloxacin in non-cytic fibrosis bronchiectasis (ORBIT-2): a randomized, double blind, placebo-controlled trial. Thorax. 2013; 68(9): 812-817
Taha EI, El-Anazi MH, El-Bagory IM, Bayomi MA. Design of liposomal coloidal systems for ocular delivery of ciprofloxacin. Saudi Pharm. J. 2014; 22(3): 231-239
Duque Aguilar, J. J., Jesús Del Valle, M. J., & Sánchez Navarro, A. (2017). Microencapsulation of ciprofloxacin in microspheres of albumin and liposomes (Albusomes). FarmaJournal, 2(2), 51–58. Retrieved from https://revistas.usal.es/cinco/index.php/2445-1355/article/view/16012
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