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Study of Genetic Susceptibility to Age-related Macular Degeneration

  • Tomás González Cabero
    Universidad de Salamanca tgonzc00[at]usal.es
  • Rogelio González Sarmiento
    Universidad de Salamanca
https://doi.org/10.14201/fj2020526372

Abstract

Age-related macular degeneration is the leading cause of severe and irreversible central vision loss in people over 50 in developed countries. This disease can be classified into two groups, wet and dry, the latter being the object of study in this paper, which is characterized by the development of choroidal neovascularization. Due to the importance of SNPs in the development of this disease, three polymorphisms belonging to the gene that encodes endogline (rs1998923, rs1330683 and rs1330684) and a polymorphism belonging to the gene that encodes preseniline-1 (rs165932) will be studied. Therefore, the objective of this work is to determine if the development of this disease is related to these polymorphisms. For this purpose, a total of 326 DNA samples were selected from patients at the University Hospital of Salamanca, of which 175 were diagnosed with wet age-related macular degeneration (cases) and 151 with cataracts (controls). The different genotypes were analysed using allelic discrimination with Taqman® probes. After performing the chi-squared test to check whether there was a statistically significant difference (p < 0.05), it is concluded that the development of wet age-related macular degeneration will not be related to these polymorphisms.

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Busel, K.; Degelsegger, A.; Lampert, D.; Lindorfer, M.; Simon, J. y Wagner, I. D.1.4 - Report on impact dimensions of the bi-regional cooperation with outlook on impact and outreach of ALCUE NET. Latin America, Caribbean and European Union. Network on Research and Innovation, 2014, en línea: https://www.zsi.at/object/publication/3761/attach/ALCUE_NET_D1_4.pdf. Consultado el 9 de abril de 2018.

Cetto, A. M. y Vessuri, H. Latin America and the Spanish-speaking Caribbean. En Unesco World Science Report, 2005: 45-76.

Chinchilla-Rodríguez, Z.; Benavent-Pérez, M.; Moya-Anegón, F. y Miguel, S. International Collaboration in Medical Research in Latin America and the Caribbean (2003-2007). Journal of the American Society for Information Science and Technology, 2012, vol. 63(11): 2223-2238. - https://doi.org/10.1002/asi.22669

Chinchilla-Rodríguez, Z.; Miguel, S.; Perianes-Rodríguez, A. y Sugimoto, C. Dependencies and autonomy in research performance: examining nanoscience and nanotechnology in emerging countries. Scientometrics, 2018a: 1-20. - https://doi.org/10.1007/s11192-018-2652-7

Chinchilla-Rodríguez, Z.; Miao, L.; Murray, D.; Robinson-García, N.; Costas, R. y Sugimoto, C. R. A global comparison of scientific mobility and collaboration according to national scientific capacities. Frontiers in Research Metrics and Analytics, 2018b, vol. 3 (17). - https://doi.org/10.3389/frma.2018.00017

Fernández, M.; Gómez, I., y Sebastian, J. La cooperación científica de los países de América Latina a través de indicadores bibliométricos. Interciencia, 1998, vol. 23 (6): 328-337.

Foladori, G. Nanotechnology in Latin America at the crossroads. Nanotechnology Law & Business, 2006, vol. 3: 205-216.

Frame, J.D. Mainstream research in Latin America and the Caribbean. Interciencia, 1977, vol. 2: 143-148

Frame, J.D. y Carpenter, M.P. International Research collaboration. Social Studies of Science, 1979, vol. 9: 481-497. - https://doi.org/10.1177/030631277900900405

Glänzel, W. National characteristics in international scientific co-authorship relations. Scientometrics, 2001, vol. 51 (1): 69-115. - https://doi.org/10.1023/A:1010512628145

Gómez, I. y Méndez, A. Are peripheral countries profiting from scientific cooperation networks?. En Weingart, P.; Sehringer, R. y Winterhager, M. (Eds.), Representations of Science and Technology. Proceedings of the international conference on science and technology indicators. Leiden: dswo Press, 1992: 112-123.

Katz, J.S. Geographical proximity and scientific collaboration. Scientometrics, 1994, vol. 31 (1): 31-43. - https://doi.org/10.1007/BF02018100

Kay, L. y Shapira, P. Developing nanotechnology in Latin America. Journal of Nanoparticle Research, 2009, vol. 11: 259-278. - https://doi.org/10.1007/s11051-008-9503-z

Kay, L., y Shapira, P. The potential of nanotechnology for equitable economic development: The case of Brazil. En Cozzens, S. y Wetmore, J. (Eds.) Nanotechnology and the challenges of equitu, equality, and development. New York: Springer, 2011: 309-329. - https://doi.org/10.1007/978-90-481-9615-9_19

Lemarchand, G. The long?term dynamics of co?authorship scientific networks: Iberoamerican Countries (1973?2006). Research Policy, 2008, vol. 41(2): 291-305. - https://doi.org/10.1016/j.respol.2011.10.009

Leydesdorff, L.; Moya?Anegón, F. y Guerrero?Bote, V. P. Journal maps, interactive overlays, and the measurement of interdisciplinarity on the basis of Scopus data (1996-2012). Journal of the Association for Information Science and Technology, 2015, vol. 66 (5): 1001-1016. - https://doi.org/10.1002/asi.23243

Lewison, G.; Fawcett-Jones, A. y Kessler, C. Latin American scientific output 1986-91 and international co-authorship patterns. Scientometrics, 1993, vol. 27 (3): 317-336. - https://doi.org/10.1007/BF02016945

Russell, J.M.; Ainsworth, S.; Del Río, J.A.; Narváez-Berthelemot, N. y Cortés, H.D. Colaboración científica entre países de la región latinoamericana. Revista Española de Documentación Científica, 2007, vol. 30 (2): 180-198. - https://doi.org/10.3989/redc.2007.v30.i2.378

Sancho, R.; Morillo, F.; De Filippo, D.; Gómez, I. y Fernández, M. Indicadores de colaboración científica inter-centros en los países de América Latina. Interciencia, 2006, vol. 31 (4), 284-292.

Ubfal, D. y Maffioli, A. The impact of funding on research collaboration: Evidence from a developing country. Research Policy, 2010, vol. 40 (9): 1269-1279. - https://doi.org/10.1016/j.respol.2011.05.023

Van Eck, N. J. y Waltman, L. VOSviewer Manual: Version 1.6.5, 2016, en línea: http://www.vosviewer.com/download/f-y2s2. Consultado el 9 de abril de 2018.

Wagner, C. S. y Leydesdorff, L. Mapping the network of global science: comparing international co?authorships from 1990 to 2000. International Journal of Technology and Globalisation, 2005, vol. 1 (2): 185?208. - https://doi.org/10.1504/IJTG.2005.007050

Study of Genetic Susceptibility to Age-related Macular Degeneration. (2020). FarmaJournal, 5(2), 63-72. https://doi.org/10.14201/fj2020526372

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Author Biographies

Tomás González Cabero

Universidad de Salamanca

Unidad de Medicina Molecular. Departamento de Medicina. Facultad de Medicina. Universidad de Salamanca. Calle Alfonso X el Sabio, s/n. 37007 Salamanca

Rogelio González Sarmiento

Universidad de Salamanca

Unidad de Medicina Molecular. Departamento de Medicina. Facultad de Medicina. Universidad de Salamanca. Calle Alfonso X el Sabio, s/n. 37007 Salamanca

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