Pathological uptake with 18-Fluorocholine versus 99mTc-MIBI in the location of the parathyroid glands in hyperparathyroidism. Systematic review and meta-analysis
Abstract Introduction: The location of the pathological parathyroid glands in hyperparathyroidism is usually carried out by means of 99mTc-sestamibi scintigraphy, which increases its precision by adding the ultrasound examination. The non-localization of the parathyroid glands increases the difficulties for surgical removal. To increase the detection of pathological glands, other radioactive tracers are used, such as methionine, fluorocholine or 18F-flurpiridaz. Objective: To establish if PET / CT with 18-Fluorocholine in patients with hyperparathyroidism increases the number of uptakes compared to the 99mTc-sestamibi scan. Method: Systematic review and meta-analysis. Two subgroups were analyzed. Subgroup 1: trials comparing both techniques as an initial exploration. Thirteen studies including 1131 examinations were selected (596 PET / CT with 18-Fluorocholine vs. 535 scintigraphy with 99mTc-sestamibi). Meta-analysis was performed following the random effects model and the odds ratio was calculated. Subgroup 2: studies that include 18-Fluorocholine as a rescue examination in patients with a previous negative study with a 99mTc-sestamibi scan. 17 articles including 412 examinations with 359 patients in which there was at least one uptake were selected. Meta-analysis of the prevalence of the number of patients in whom there was at least one uptake was performed using the random effects model. Results: Subgroup 1: The number of patients in which at least one uptake occurs is significantly higher with the 18-Fluorocholine examinations (OR 4.264, 95% CI 2.400-7.577). The prevalence of uptake with 18-Fluorocholine is 0.91 [0.86, 0.95] and with sestamibi 0.68 [0.56, 0.80]. Subgroup 2: the prevalence of uptake among patients with previous negative MIBI studies was 0.90 [0.87, 0.94]. The probability of detection of both techniques in this group reaches 0.98. Publication bias in the meta-analyzes is low. Discussion: 18-Fluorocholine protocols provide higher precision, clearer images, with faster acquisition as well as being readily available for most PET / CT centers. Conclusion: The PET / CT study with 18-Fluorocholine can be recommended as a study for the location of pathological parathyroid glands after studies with negative MIBI.
- Referencias
- Cómo citar
- Del mismo autor
- Métricas
Hindié E, Zanotti-Fregonara P, Tabarin A, Rubello D, Morelec I, Wagner T, et al. The role of radionuclide imaging in the surgical management of primary hyperparathyroidism. J Nucl Med. 2015 May 1;56(5):737-44. https://doi.org/10.2967/jnumed.115.156018
Lussey-Lepoutre C, Trésallet C, Ghander C, Morelec I, Najah H, Kasereka-kisenge F, et al. Rôle de l'imagerie dans le bilan préopératoire des hyperparathyroïdies primaires. Med Nucl. 2018 Jan 1;42(1):49-58. https://doi.org/10.1016/j.mednuc.2017.12.001
Prior JO. New scintigraphic methods for parathyroid imaging. Ann Endocrinol (Paris). 2015 May 1;76(2):145-7. https://doi.org/10.1016/j.ando.2015.03.026
Weber T, Luster M. C-11-Methionin-PET/CT zur Lokalisation von Nebenschilddrüsenadenomen. Vol. 85, Chirurg. Springer Verlag; 2014. p. 601-6. https://doi.org/10.1007/s00104-013-2695-5
Grassetto G, Alavi A, Rubello D. PET and Parathyroid. Vol. 2, PET Clinics. 2007. p. 385-93. https://doi.org/10.1016/j.cpet.2008.04.005
Kettle AG, O'Doherty MJ. Parathyroid Imaging: How Good Is It and How Should It Be Done? Semin Nucl Med. 2006 Jul;36(3):206-11. https://doi.org/10.1053/j.semnuclmed.2006.03.003
Imperiale A, Taïeb D, Hindié E. 18 F-Fluorocholine PET/CT as a second line nuclear imaging technique before surgery for primary hyperparathyroidism. Vol. 45, European Journal of Nuclear Medicine and Molecular Imaging. Springer Berlin Heidelberg; 2018. p. 654-7. https://doi.org/10.1007/s00259-017-3920-0
García-Talavera San Miguel P, Gómez-Caminero López F, Villanueva Curto JG, Tamayo Alonso MP, Martín Gómez ME. Update of the role of Nuclear Medicine techniques in the pre-surgical localization of primary hyperparathyroidism. Rev Esp Med Nucl Imagen Mol. 2019 Mar 1;38(2):123-35. https://doi.org/10.1016/j.remnie.2019.01.006
Mapelli P, Busnardo E, Magnani P, Freschi M, Picchio M, Gianolli L, et al. Incidental finding of parathyroid adenoma with 11C-choline PET/CT. Clin Nucl Med. 2012 Jun;37(6):593-5. https://doi.org/10.1097/RLU.0b013e31824c5ffc
Quak E, Lheureux S, Reznik Y, Bardet S, Aide N. F18-choline, a novel PET tracer for parathyroid adenoma? Vol. 98, Journal of Clinical Endocrinology and Metabolism. 2013. p. 3111-2. https://doi.org/10.1210/jc.2013-2084
Hodolic M, Huchet V, Balogova S, Michaud L, Kerrou K, Nataf V, et al. Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer. Radiol Oncol. 2014 Sep 1;48(3):228-34. https://doi.org/10.2478/raon-2013-0075
Parvinian A, Martin-Macintosh EL, Goenka AH, Durski JM, Mullan BP, Kemp BJ, et al. 11C-choline PET/CT for detection and localization of parathyroid adenomas. Am J Roentgenol. 2018 Feb 1;210(2):418-22. https://doi.org/10.2214/AJR.17.18312
Kluijfhout WP, Vorselaars WMCM, Vriens MR, Borel Rinkes IHM, Valk GD, De Keizer B. Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT-CT, ultrasound and first results of 18F-fluorocholine PET-CT. Eur J Radiol. 2015 Sep 1;84(9):1745-51. https://doi.org/10.1016/j.ejrad.2015.05.024
Michaud L, Balogova S, Burgess A, Ohnona J, Huchet V, Kerrou K, et al. A pilot comparison of 18F-fluorocholine PET/CT, ultrasonography and 123I/99mTc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism: Influence of. Med (United States). 2015;94(41). https://doi.org/10.1097/MD.0000000000001701
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015 Jan 2;350:g7647. https://doi.org/10.1136/bmj.g7647
Centro Cochrane Iberoamericano traductores. Manual Cochrane de Revisiones Sistemáticas de Intervenciones, versión 5.1.0 [actualizada en marzo de 2011]. Barcelona; 2012. 639 p.
Thanseer N, Bhadada SK, Sood A, Mittal BR, Behera A, Gorla AKR, et al. Comparative Effectiveness of Ultrasonography, 99mTc-Sestamibi, and 18F-Fluorocholine PET/CT in Detecting Parathyroid Adenomas in Patients With Primary Hyperparathyroidism. Clin Nucl Med. 2017;42(12):e491-7. https://doi.org/10.1097/RLU.0000000000001845
Michaud L, Burgess A, Huchet V, Lefèvre M, Tassart M, Ohnona J, et al. Is 18F-fluorocholine-positron emission tomography/ computerized tomography a new imaging tool for detecting hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism? J Clin Endocrinol Metab. 2014 Dec 1;99(12):4531-6. https://doi.org/10.1210/jc.2014-2821
Khafif A, Masalha M, Landsberg R, Domachevsky L, Bernstine H, Groshar D, et al. The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas. Eur Arch Oto-Rhino-Laryngology. 2019;276(5):1509-16. https://doi.org/10.1007/s00405-019-05301-2
Lezaic L, Rep S, Sever MJ, Kocjan T, Hocevar M, Fettich J. 18F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study. Eur J Nucl Med Mol Imaging. 2014;41(11):2083-9. https://doi.org/10.1007/s00259-014-2837-0
Orevi M, Freedman N, Mishani E, Bocher M, Jacobson O, Krausz Y. Localization of parathyroid adenoma by 11C-Choline PET/CT preliminary results. Clin Nucl Med. 2014;39(12):1033-8. https://doi.org/10.1097/RLU.0000000000000607
Beheshti M, Hehenwarter L, Paymani Z, Rendl G, Imamovic L, Rettenbacher R, et al. 18F-Fluorocholine PET/CT in the assessment of primary hyperparathyroidism compared with 99mTc-MIBI or 99mTc-tetrofosmin SPECT/CT: a prospective dual-centre study in 100 patients. Eur J Nucl Med Mol Imaging. 2018 Sep 1;45(10):1762-71. https://doi.org/10.1007/s00259-018-3980-9
Araz, C. Soydal, E. Ozkan, M. Kir, E. İbis, S. Gullu MF, Erdogan, R. Emral ONK. The Efficacy of 18F Choline PET/CT in comparison to Tc99m MIBI SPECT/CT in the Localisation of Hyperfunctioning Parathyroid Gland in primary Hyperparathyroidism. Eur J Nucl Med Mol Imaging. 2018;45(Suppl. 1):S89-90. https://doi.org/10.1097/MNM.0000000000000899
Araz M, Soydal Ç, Özkan E, Kır MK, İbiş E, Güllü S, et al. The efficacy of fluorine-18-choline PET/CT in comparison with 99mTc-MIBI SPECT/CT in the localization of a hyperfunctioning parathyroid gland in primary hyperparathyroidism. Nucl Med Commun. 2018;39(11):989-94. https://doi.org/10.1097/MNM.0000000000000899
Bossert I, Chytiris S, Hodolic M, Croce L, Mansi L, Chiovato L, et al. PETC/CT with 18 F-Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism. J Endocrinol Invest. 2019 Apr 2;42(4):419-26. https://doi.org/10.1007/s40618-018-0931-z
Imamovic L. F18 Choline PET-CT: an accurate diagnostic tool for the detection of parathyroid adenoma? Mol imaging Biol Conf world Mol imaging Congr 2016 United states Conf start 20160907 Conf end 20160910. 2016;(2 Supplement).
Hocevar M, Lezaic L, Rep S, Zaletel K, Kocjan T, Sever MJ, et al. Focused parathyroidectomy without intraoperative parathormone testing is safe after pre-operative localization with 18F-Fluorocholine PET/CT. Eur J Surg Oncol. 2017 Jan 1;43(1):133-7. https://doi.org/10.1016/j.ejso.2016.09.016
Kluijfhout WP, Vorselaars WMCM, Van Den Berk SAM, Vriens MR, Borel Rinkes IHM, Valk GD, et al. Fluorine-18 fluorocholine PET-CT localizes hyperparathyroidism in patients with inconclusive conventional imaging: A multicenter study from the Netherlands. Nucl Med Commun. 2016 Nov 1;37(12):1246-52. https://doi.org/10.1097/MNM.0000000000000595
Liu Y, Dang Y, Huo L, Hu Y, Wang O, Liu H, et al. Preoperative localisation of adenomas in primary hyperparathyroidism: the value of 11 C-choline PET/CT in patients with negative or discordant ultrasonography and 99m Tc-Sesta-MIBI-SPECT/CT. J Nucl Med. 2019 Oct 10;jnumed.119.233213. https://doi.org/10.2967/jnumed.119.233213
Christakis I, Khan S, Sadler GP, Gleeson F V., Bradley KM, Mihai R. 18Fluorocholine PET/CT scanning with arterial phase-enhanced CT is useful for persistent/ recurrent primary hyperparathyroidism: First UK case series results. In: Annals of the Royal College of Surgeons of England. Royal College of Surgeons of England; 2019. p. 501-7. https://doi.org/10.1308/rcsann.2019.0059
Boccalatte LA, Higuera F, Gómez NL, De La Torre AY, Mazzaro EL, Galich AM, et al. Usefulness of 18F-fluorocholine positron emission tomography-computed tomography in locating lesions in hyperparathyroidism: A systematic review. Vol. 145, JAMA Otolaryngology - Head and Neck Surgery. American Medical Association; 2019. p. 743-50. https://doi.org/10.1001/jamaoto.2019.0574
Grimaldi S, Young J, Kamenicky P, Hartl D, Terroir M, Leboulleux S, et al. Challenging pre-surgical localization of hyperfunctioning parathyroid glands in primary hyperparathyroidism: the added value of 18F-Fluorocholine PET/CT. Eur J Nucl Med Mol Imaging. 2018 Sep 1;45(10):1772-80. https://doi.org/10.1007/s00259-018-4018-z
Huber GF, Hüllner M, Schmid C, Brunner A, Sah B, Vetter D, et al. Benefit of 18 F-fluorocholine PET imaging in parathyroid surgery. Vol. 28, European Radiology. Springer Verlag; 2018. p. 2700-7. https://doi.org/10.1007/s00330-017-5190-4
Treglia G, Sadeghi R, Schalin-Jäntti C, Caldarella C, Ceriani L, Giovanella L. Detection rate of 99mTc-MIBI single photon emission computed tomography (SPECT)/CT in preoperative planning for patients with primary hyperparathyroidism: A meta-analysis. Vol. 38, Head and Neck. John Wiley and Sons Inc.; 2016. p. E2159-72. https://doi.org/10.1002/hed.24027
Piccardo A, Trimboli P, Rutigliani M, Puntoni M, Foppiani L, Bacigalupo L, et al. Additional value of integrated 18 F-choline PET/4D contrast-enhanced CT in the localization of hyperfunctioning parathyroid glands and correlation with molecular profile. Eur J Nucl Med Mol Imaging. 2019;46(3):766-75. https://doi.org/10.1007/s00259-018-4147-4
Zajickova, K; Zogala, D; Kubinyi J. Parathyroid Imaging by 18F-Fluorocholine PET/CT in Patients With Primary Hyperparathyroidism and Inconclusive Conventional Methods: Clinico-Pathological Correlations. Physiol Res. 2018 Nov 30;S551-7. https://doi.org/10.33549/physiolres.934029
Kluijfhout WP, Pasternak JD, Gosnell JE, Shen WT, Duh QY, Vriens MR, et al. 18F fluorocholine PET/MR imaging in patients with primary hyperparathyroidism and inconclusive conventional imaging: A prospective pilot study. Radiology. 2017 Aug 1;284(2):460-7. https://doi.org/10.1148/radiol.2016160768
Quak E, Blanchard D, Houdu B, Le Roux Y, Ciappuccini R, Lireux B, et al. F18-choline PET/CT guided surgery in primary hyperparathyroidism when ultrasound and MIBI SPECT/CT are negative or inconclusive: the APACH1 study. Eur J Nucl Med Mol Imaging. 2018 Apr 1;45(4):658-66. https://doi.org/10.1007/s00259-017-3911-1
M. I. Morales-Lozano, C. Perdomo1, F. Grisanti1, O. Ajuria J, Rosales, C. Silva JA. Primary hyperparathyroidism and negative conventional imaging: value of 11C-Methionine PET/CT and comparison with 11C-Choline PET/CT. Eur J Nucl Med Mol Imaging. 2018;45(Suppl. 1):S88-9.
G. Bera, C. Amadou, M. Ezziane, L. Chami, T. Delbot, A. Rouxel M, Leban, G. Herve, F. Menegaux, L. Leenhardt, A. Kas, C. Tresalet C, Ghander CL-L. 18F-fluorocholine PET/CT and parathyroid 4D Computed Tomography: First results of an alternative and efficient imaging tool in reoperative patients with primary hyperparathyroidism. Eur J Nucl Med Mol Imaging. 2018;45(Suppl. 1):S90.
Amadou C, Bera G, Ezziane M, Chami L, Delbot T, Rouxel A, et al. 18F-Fluorocholine PET/CT and Parathyroid 4D Computed Tomography for Primary Hyperparathyroidism: The Challenge of Reoperative Patients. World J Surg. 2019 May 15;43(5):1232-42. https://doi.org/10.1007/s00268-019-04910-6
Treglia G, Piccardo A, Imperiale A, Strobel K, Kaufmann PA, Prior JO, et al. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2019;46(3):751-65. https://doi.org/10.1007/s00259-018-4123-z
Kim SJ, Lee SW, Jeong SY, Pak K, Kim K. Diagnostic Performance of F-18 Fluorocholine PET/CT for Parathyroid Localization in Hyperparathyroidism: a Systematic Review and Meta-Analysis. Horm Cancer. 2018;9(6):440-7. https://doi.org/10.1007/s12672-018-0347-4
Treglia G, Trimboli P, Huellner M, Giovanella L. Imaging in primary hyperparathyroidism: Focus on the evidence-based diagnostic performance of different methods. Vol. 43, Minerva Endocrinologica. Edizioni Minerva Medica; 2018. p. 133-43. https://doi.org/10.23736/S0391-1977.17.02685-2
Broos WAM, Wondergem M, Knol RJJ, van der Zant FM. Parathyroid imaging with 18F-fluorocholine PET/CT as a first-line imaging modality in primary hyperparathyroidism: a retrospective cohort study. EJNMMI Res. 2019 Dec 1;9(1). https://doi.org/10.1186/s13550-019-0544-3
Kluijfhout WP, Pasternak JD, Drake FT, Beninato T, Gosnell JE, Shen WT, et al. Use of PET tracers for parathyroid localization: a systematic review and meta-analysis. Langenbeck's Arch Surg. 2016 Nov 1;401(7):925-35. https://doi.org/10.1007/s00423-016-1425-0
Yuan L, Liu J, Kan Y, Yang J, Wang X. The diagnostic value of 11C-methionine PET in hyperparathyroidism with negative 99mTc-MIBI SPECT: A meta-analysis. Vol. 58, Acta Radiologica. SAGE Publications Inc.; 2017. p. 558-64. https://doi.org/10.1177/0284185116661878
Caldarella C, Treglia G, Isgrò MA, Giordano A. Diagnostic performance of positron emission tomography using 11C-methionine in patients with suspected parathyroid adenoma: A meta-analysis. Endocrine. 2013 Feb;43(1):78-83. https://doi.org/10.1007/s12020-012-9746-4
Broos WAM, Van Der Zant FM, Knol RJJ, Wondergem M. Choline PET/CT in parathyroid imaging: a systematic review. Vol. 40, Nuclear Medicine Communications. Lippincott Williams and Wilkins; 2019. p. 96-105. https://doi.org/10.1097/MNM.0000000000000952
Rep S, Hocevar M, Vaupotic J, Zdesar U, Zaletel K, Lezaic L. 18F-choline PET/CT for parathyroid scintigraphy: Significantly lower radiation exposure of patients in comparison to conventional nuclear medicine imaging approaches. J Radiol Prot. 2018 Mar 1;38(1):343-56. https://doi.org/10.1088/1361-6498/aaa86f
Lussey-Lepoutre C, Trésallet C, Ghander C, Morelec I, Najah H, Kasereka-kisenge F, et al. Rôle de l'imagerie dans le bilan préopératoire des hyperparathyroïdies primaires. Med Nucl. 2018 Jan 1;42(1):49-58. https://doi.org/10.1016/j.mednuc.2017.12.001
Prior JO. New scintigraphic methods for parathyroid imaging. Ann Endocrinol (Paris). 2015 May 1;76(2):145-7. https://doi.org/10.1016/j.ando.2015.03.026
Weber T, Luster M. C-11-Methionin-PET/CT zur Lokalisation von Nebenschilddrüsenadenomen. Vol. 85, Chirurg. Springer Verlag; 2014. p. 601-6. https://doi.org/10.1007/s00104-013-2695-5
Grassetto G, Alavi A, Rubello D. PET and Parathyroid. Vol. 2, PET Clinics. 2007. p. 385-93. https://doi.org/10.1016/j.cpet.2008.04.005
Kettle AG, O'Doherty MJ. Parathyroid Imaging: How Good Is It and How Should It Be Done? Semin Nucl Med. 2006 Jul;36(3):206-11. https://doi.org/10.1053/j.semnuclmed.2006.03.003
Imperiale A, Taïeb D, Hindié E. 18 F-Fluorocholine PET/CT as a second line nuclear imaging technique before surgery for primary hyperparathyroidism. Vol. 45, European Journal of Nuclear Medicine and Molecular Imaging. Springer Berlin Heidelberg; 2018. p. 654-7. https://doi.org/10.1007/s00259-017-3920-0
García-Talavera San Miguel P, Gómez-Caminero López F, Villanueva Curto JG, Tamayo Alonso MP, Martín Gómez ME. Update of the role of Nuclear Medicine techniques in the pre-surgical localization of primary hyperparathyroidism. Rev Esp Med Nucl Imagen Mol. 2019 Mar 1;38(2):123-35. https://doi.org/10.1016/j.remnie.2019.01.006
Mapelli P, Busnardo E, Magnani P, Freschi M, Picchio M, Gianolli L, et al. Incidental finding of parathyroid adenoma with 11C-choline PET/CT. Clin Nucl Med. 2012 Jun;37(6):593-5. https://doi.org/10.1097/RLU.0b013e31824c5ffc
Quak E, Lheureux S, Reznik Y, Bardet S, Aide N. F18-choline, a novel PET tracer for parathyroid adenoma? Vol. 98, Journal of Clinical Endocrinology and Metabolism. 2013. p. 3111-2. https://doi.org/10.1210/jc.2013-2084
Hodolic M, Huchet V, Balogova S, Michaud L, Kerrou K, Nataf V, et al. Incidental uptake of 18F-fluorocholine (FCH) in the head or in the neck of patients with prostate cancer. Radiol Oncol. 2014 Sep 1;48(3):228-34. https://doi.org/10.2478/raon-2013-0075
Parvinian A, Martin-Macintosh EL, Goenka AH, Durski JM, Mullan BP, Kemp BJ, et al. 11C-choline PET/CT for detection and localization of parathyroid adenomas. Am J Roentgenol. 2018 Feb 1;210(2):418-22. https://doi.org/10.2214/AJR.17.18312
Kluijfhout WP, Vorselaars WMCM, Vriens MR, Borel Rinkes IHM, Valk GD, De Keizer B. Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT-CT, ultrasound and first results of 18F-fluorocholine PET-CT. Eur J Radiol. 2015 Sep 1;84(9):1745-51. https://doi.org/10.1016/j.ejrad.2015.05.024
Michaud L, Balogova S, Burgess A, Ohnona J, Huchet V, Kerrou K, et al. A pilot comparison of 18F-fluorocholine PET/CT, ultrasonography and 123I/99mTc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism: Influence of. Med (United States). 2015;94(41). https://doi.org/10.1097/MD.0000000000001701
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015 Jan 2;350:g7647. https://doi.org/10.1136/bmj.g7647
Centro Cochrane Iberoamericano traductores. Manual Cochrane de Revisiones Sistemáticas de Intervenciones, versión 5.1.0 [actualizada en marzo de 2011]. Barcelona; 2012. 639 p.
Thanseer N, Bhadada SK, Sood A, Mittal BR, Behera A, Gorla AKR, et al. Comparative Effectiveness of Ultrasonography, 99mTc-Sestamibi, and 18F-Fluorocholine PET/CT in Detecting Parathyroid Adenomas in Patients With Primary Hyperparathyroidism. Clin Nucl Med. 2017;42(12):e491-7. https://doi.org/10.1097/RLU.0000000000001845
Michaud L, Burgess A, Huchet V, Lefèvre M, Tassart M, Ohnona J, et al. Is 18F-fluorocholine-positron emission tomography/ computerized tomography a new imaging tool for detecting hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism? J Clin Endocrinol Metab. 2014 Dec 1;99(12):4531-6. https://doi.org/10.1210/jc.2014-2821
Khafif A, Masalha M, Landsberg R, Domachevsky L, Bernstine H, Groshar D, et al. The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas. Eur Arch Oto-Rhino-Laryngology. 2019;276(5):1509-16. https://doi.org/10.1007/s00405-019-05301-2
Lezaic L, Rep S, Sever MJ, Kocjan T, Hocevar M, Fettich J. 18F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study. Eur J Nucl Med Mol Imaging. 2014;41(11):2083-9. https://doi.org/10.1007/s00259-014-2837-0
Orevi M, Freedman N, Mishani E, Bocher M, Jacobson O, Krausz Y. Localization of parathyroid adenoma by 11C-Choline PET/CT preliminary results. Clin Nucl Med. 2014;39(12):1033-8. https://doi.org/10.1097/RLU.0000000000000607
Beheshti M, Hehenwarter L, Paymani Z, Rendl G, Imamovic L, Rettenbacher R, et al. 18F-Fluorocholine PET/CT in the assessment of primary hyperparathyroidism compared with 99mTc-MIBI or 99mTc-tetrofosmin SPECT/CT: a prospective dual-centre study in 100 patients. Eur J Nucl Med Mol Imaging. 2018 Sep 1;45(10):1762-71. https://doi.org/10.1007/s00259-018-3980-9
Araz, C. Soydal, E. Ozkan, M. Kir, E. İbis, S. Gullu MF, Erdogan, R. Emral ONK. The Efficacy of 18F Choline PET/CT in comparison to Tc99m MIBI SPECT/CT in the Localisation of Hyperfunctioning Parathyroid Gland in primary Hyperparathyroidism. Eur J Nucl Med Mol Imaging. 2018;45(Suppl. 1):S89-90. https://doi.org/10.1097/MNM.0000000000000899
Araz M, Soydal Ç, Özkan E, Kır MK, İbiş E, Güllü S, et al. The efficacy of fluorine-18-choline PET/CT in comparison with 99mTc-MIBI SPECT/CT in the localization of a hyperfunctioning parathyroid gland in primary hyperparathyroidism. Nucl Med Commun. 2018;39(11):989-94. https://doi.org/10.1097/MNM.0000000000000899
Bossert I, Chytiris S, Hodolic M, Croce L, Mansi L, Chiovato L, et al. PETC/CT with 18 F-Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism. J Endocrinol Invest. 2019 Apr 2;42(4):419-26. https://doi.org/10.1007/s40618-018-0931-z
Imamovic L. F18 Choline PET-CT: an accurate diagnostic tool for the detection of parathyroid adenoma? Mol imaging Biol Conf world Mol imaging Congr 2016 United states Conf start 20160907 Conf end 20160910. 2016;(2 Supplement).
Hocevar M, Lezaic L, Rep S, Zaletel K, Kocjan T, Sever MJ, et al. Focused parathyroidectomy without intraoperative parathormone testing is safe after pre-operative localization with 18F-Fluorocholine PET/CT. Eur J Surg Oncol. 2017 Jan 1;43(1):133-7. https://doi.org/10.1016/j.ejso.2016.09.016
Kluijfhout WP, Vorselaars WMCM, Van Den Berk SAM, Vriens MR, Borel Rinkes IHM, Valk GD, et al. Fluorine-18 fluorocholine PET-CT localizes hyperparathyroidism in patients with inconclusive conventional imaging: A multicenter study from the Netherlands. Nucl Med Commun. 2016 Nov 1;37(12):1246-52. https://doi.org/10.1097/MNM.0000000000000595
Liu Y, Dang Y, Huo L, Hu Y, Wang O, Liu H, et al. Preoperative localisation of adenomas in primary hyperparathyroidism: the value of 11 C-choline PET/CT in patients with negative or discordant ultrasonography and 99m Tc-Sesta-MIBI-SPECT/CT. J Nucl Med. 2019 Oct 10;jnumed.119.233213. https://doi.org/10.2967/jnumed.119.233213
Christakis I, Khan S, Sadler GP, Gleeson F V., Bradley KM, Mihai R. 18Fluorocholine PET/CT scanning with arterial phase-enhanced CT is useful for persistent/ recurrent primary hyperparathyroidism: First UK case series results. In: Annals of the Royal College of Surgeons of England. Royal College of Surgeons of England; 2019. p. 501-7. https://doi.org/10.1308/rcsann.2019.0059
Boccalatte LA, Higuera F, Gómez NL, De La Torre AY, Mazzaro EL, Galich AM, et al. Usefulness of 18F-fluorocholine positron emission tomography-computed tomography in locating lesions in hyperparathyroidism: A systematic review. Vol. 145, JAMA Otolaryngology - Head and Neck Surgery. American Medical Association; 2019. p. 743-50. https://doi.org/10.1001/jamaoto.2019.0574
Grimaldi S, Young J, Kamenicky P, Hartl D, Terroir M, Leboulleux S, et al. Challenging pre-surgical localization of hyperfunctioning parathyroid glands in primary hyperparathyroidism: the added value of 18F-Fluorocholine PET/CT. Eur J Nucl Med Mol Imaging. 2018 Sep 1;45(10):1772-80. https://doi.org/10.1007/s00259-018-4018-z
Huber GF, Hüllner M, Schmid C, Brunner A, Sah B, Vetter D, et al. Benefit of 18 F-fluorocholine PET imaging in parathyroid surgery. Vol. 28, European Radiology. Springer Verlag; 2018. p. 2700-7. https://doi.org/10.1007/s00330-017-5190-4
Treglia G, Sadeghi R, Schalin-Jäntti C, Caldarella C, Ceriani L, Giovanella L. Detection rate of 99mTc-MIBI single photon emission computed tomography (SPECT)/CT in preoperative planning for patients with primary hyperparathyroidism: A meta-analysis. Vol. 38, Head and Neck. John Wiley and Sons Inc.; 2016. p. E2159-72. https://doi.org/10.1002/hed.24027
Piccardo A, Trimboli P, Rutigliani M, Puntoni M, Foppiani L, Bacigalupo L, et al. Additional value of integrated 18 F-choline PET/4D contrast-enhanced CT in the localization of hyperfunctioning parathyroid glands and correlation with molecular profile. Eur J Nucl Med Mol Imaging. 2019;46(3):766-75. https://doi.org/10.1007/s00259-018-4147-4
Zajickova, K; Zogala, D; Kubinyi J. Parathyroid Imaging by 18F-Fluorocholine PET/CT in Patients With Primary Hyperparathyroidism and Inconclusive Conventional Methods: Clinico-Pathological Correlations. Physiol Res. 2018 Nov 30;S551-7. https://doi.org/10.33549/physiolres.934029
Kluijfhout WP, Pasternak JD, Gosnell JE, Shen WT, Duh QY, Vriens MR, et al. 18F fluorocholine PET/MR imaging in patients with primary hyperparathyroidism and inconclusive conventional imaging: A prospective pilot study. Radiology. 2017 Aug 1;284(2):460-7. https://doi.org/10.1148/radiol.2016160768
Quak E, Blanchard D, Houdu B, Le Roux Y, Ciappuccini R, Lireux B, et al. F18-choline PET/CT guided surgery in primary hyperparathyroidism when ultrasound and MIBI SPECT/CT are negative or inconclusive: the APACH1 study. Eur J Nucl Med Mol Imaging. 2018 Apr 1;45(4):658-66. https://doi.org/10.1007/s00259-017-3911-1
M. I. Morales-Lozano, C. Perdomo1, F. Grisanti1, O. Ajuria J, Rosales, C. Silva JA. Primary hyperparathyroidism and negative conventional imaging: value of 11C-Methionine PET/CT and comparison with 11C-Choline PET/CT. Eur J Nucl Med Mol Imaging. 2018;45(Suppl. 1):S88-9.
G. Bera, C. Amadou, M. Ezziane, L. Chami, T. Delbot, A. Rouxel M, Leban, G. Herve, F. Menegaux, L. Leenhardt, A. Kas, C. Tresalet C, Ghander CL-L. 18F-fluorocholine PET/CT and parathyroid 4D Computed Tomography: First results of an alternative and efficient imaging tool in reoperative patients with primary hyperparathyroidism. Eur J Nucl Med Mol Imaging. 2018;45(Suppl. 1):S90.
Amadou C, Bera G, Ezziane M, Chami L, Delbot T, Rouxel A, et al. 18F-Fluorocholine PET/CT and Parathyroid 4D Computed Tomography for Primary Hyperparathyroidism: The Challenge of Reoperative Patients. World J Surg. 2019 May 15;43(5):1232-42. https://doi.org/10.1007/s00268-019-04910-6
Treglia G, Piccardo A, Imperiale A, Strobel K, Kaufmann PA, Prior JO, et al. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2019;46(3):751-65. https://doi.org/10.1007/s00259-018-4123-z
Kim SJ, Lee SW, Jeong SY, Pak K, Kim K. Diagnostic Performance of F-18 Fluorocholine PET/CT for Parathyroid Localization in Hyperparathyroidism: a Systematic Review and Meta-Analysis. Horm Cancer. 2018;9(6):440-7. https://doi.org/10.1007/s12672-018-0347-4
Treglia G, Trimboli P, Huellner M, Giovanella L. Imaging in primary hyperparathyroidism: Focus on the evidence-based diagnostic performance of different methods. Vol. 43, Minerva Endocrinologica. Edizioni Minerva Medica; 2018. p. 133-43. https://doi.org/10.23736/S0391-1977.17.02685-2
Broos WAM, Wondergem M, Knol RJJ, van der Zant FM. Parathyroid imaging with 18F-fluorocholine PET/CT as a first-line imaging modality in primary hyperparathyroidism: a retrospective cohort study. EJNMMI Res. 2019 Dec 1;9(1). https://doi.org/10.1186/s13550-019-0544-3
Kluijfhout WP, Pasternak JD, Drake FT, Beninato T, Gosnell JE, Shen WT, et al. Use of PET tracers for parathyroid localization: a systematic review and meta-analysis. Langenbeck's Arch Surg. 2016 Nov 1;401(7):925-35. https://doi.org/10.1007/s00423-016-1425-0
Yuan L, Liu J, Kan Y, Yang J, Wang X. The diagnostic value of 11C-methionine PET in hyperparathyroidism with negative 99mTc-MIBI SPECT: A meta-analysis. Vol. 58, Acta Radiologica. SAGE Publications Inc.; 2017. p. 558-64. https://doi.org/10.1177/0284185116661878
Caldarella C, Treglia G, Isgrò MA, Giordano A. Diagnostic performance of positron emission tomography using 11C-methionine in patients with suspected parathyroid adenoma: A meta-analysis. Endocrine. 2013 Feb;43(1):78-83. https://doi.org/10.1007/s12020-012-9746-4
Broos WAM, Van Der Zant FM, Knol RJJ, Wondergem M. Choline PET/CT in parathyroid imaging: a systematic review. Vol. 40, Nuclear Medicine Communications. Lippincott Williams and Wilkins; 2019. p. 96-105. https://doi.org/10.1097/MNM.0000000000000952
Rep S, Hocevar M, Vaupotic J, Zdesar U, Zaletel K, Lezaic L. 18F-choline PET/CT for parathyroid scintigraphy: Significantly lower radiation exposure of patients in comparison to conventional nuclear medicine imaging approaches. J Radiol Prot. 2018 Mar 1;38(1):343-56. https://doi.org/10.1088/1361-6498/aaa86f
Pardal Refoyo, J. L., Tamayo Alonso, P., Ferreira Cendón, S., & Martín Gómez, E. (2022). Pathological uptake with 18-Fluorocholine versus 99mTc-MIBI in the location of the parathyroid glands in hyperparathyroidism. Systematic review and meta-analysis. Revista ORL, 15(1), e29465. https://doi.org/10.14201/orl.29465
Most read articles by the same author(s)
- Estela Cristina Prieto Maillo, Sofía Ferreira Cendón, María José Fernández Nava, Ramón Antonio Martínez Carranza, José Carlos Gómez Sánchez, Ángel Batuecas Caletrío, Impact of Tinnitus in Patients with Ménière's Disease , Revista ORL: Vol. 12 No. 3 (2021)
- Cristina Villaoslada Fuentes, María José Fernández-Nava, Sofía Ferreira Cendón, Rosana Villaoslada Fuentes, Hortensia Sánchez Gómez, Ángel Batuecas Caletrío, Hearing loss after intratympanic gentamicin in Ménière's disease. Retrospective study , Revista ORL: Vol. 12 No. 3 (2021)
- Rosana Villaoslada Fuentes, Ramón Antonio Martínez Carranza, Gianni Mercy García Núñez, Erwin Racines Alava, Sofía Ferreira Cendón, María José Fernández Nava, Juan Carlos Del Pozo De Dios, ADENOMA DE CÉLULAS BASALES DE SENO MAXILAR, A PROPÓSITO DE UN CASO , Revista ORL: SORIA 2019
- Montserrat Martín-Alonso, Pablo Prieto Matos, Ana Fe Bajo Delgado, María Teresa Mories Álvarez, Ana Isabel Sánchez Marcos, José Luis Pardal Refoyo, Thyroid nodules in children , Revista ORL: Vol. 12 No. 4 (2021)
- María José Fernández-Nava, Sofía Ferreira Cendón, Sara Alonso de la Iglesia, María de las Mercedes Cecilio Rivas, Ana Belén Alonso San Eloy, Ángel Batuecas Caletrío, Stability limits in different posturography patterns. Cohort study. , Revista ORL: Vol. 13 No. 4 (2022)
Downloads
Download data is not yet available.
+
−