Thyroid physiology. Disfunction and laboratory tests in thyroid diseases
Abstract The study of functional thyroid pathology requires an adequate knowledge of the processes involved in the synthesis, secretion, transport, metabolism and regulation and mechanism of action of thyroid hormones In the initial management of thyroid dysfunction, the interpretation of the values of Thyrotropin (TSH) and peripheral hormones (free T4 and T3) will let us know if the etiology is in the thyroid or outside the thyroid. Objective: to expose some basic knowledge about the physiology and functional alterations of the thyroid gland.
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2. Douglas SR. Thyroid hormone synthesis and physiology. En Cooper DS, Mulder JE, Editors. Uptodate: 2019. Disponible en https://www.uptodate.com. Consultado el 01/09/2019
3. Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev. 2001;22(4):451–76.
4. Bernal J, Guadaño-Ferraz A, Morte B. Thyroid hormone transporters--functions and clinical implications [published correction appears in Nat Rev Endocrinol. 2015 Sep;11(9):506] [published correction appears in Nat Rev Endocrinol. 2015;11(12):690]. Nat Rev Endocrinol. 2015;11(7):406–17.
5. Surks MI, Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab. 2007;92(12):4575–82.
6. Dufour DR. Laboratory tests of thyroid function: uses and limitations. Endocrinol Metab Clin North Am. 2007;36(3):579–94.
Santiago-Peña, L. F. (2019). Thyroid physiology. Disfunction and laboratory tests in thyroid diseases. Revista ORL, 11(3), 253–257. https://doi.org/10.14201/orl.21514
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